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Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
J Alzheimers Dis. 2020; 77(2):781-794.JA

Abstract

BACKGROUND

Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults.

OBJECTIVE

To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis.

METHODS

Medline (PubMed), EMBASE, and Cochrane databases were used to search the literature though August 8, 2019. We included observational population-based studies evaluating the association between concentrations or intake levels of vitamins B6, B12, or folate and cognition in older adults aged ≥45 years. The quality of all studies was assessed by the modified Newcastle-Ottawa Scale. Odds ratios (ORs) and hazard ratios (HRs) were analyzed by the random-effects model. Sensitivity analyses were conducted by excluding the studies with significant heterogeneity.

RESULTS

Twenty-one observational studies with sample sizes ranging from 155-7030 were included in the meta-analysis. Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61-0.97) and folate concentration (OR = 0.68, 95% CI = 0.51-0.90) were associated with better cognition in cross-sectional studies, but not in sensitivity analyses or prospective studies. High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk. Prospective studies did not provide substantial evidence for the relationship.

CONCLUSION

The results from our meta-analysis suggest that vitamins B12, B6, and folate may not be modifiable risk factors for slowing cognitive decline among community-dwelling older individuals.

Authors+Show Affiliations

Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China. NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, China. Key Laboratory of Public Health Safety of Ministry of Education (Fudan University), Shanghai, China.Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China. NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, China. Key Laboratory of Public Health Safety of Ministry of Education (Fudan University), Shanghai, China.School of Public Health, Zhejiang University, Hangzhou, China.Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

32773392

Citation

Zhang, Chenbo, et al. "Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: a Systematic Review and Meta-Analysis." Journal of Alzheimer's Disease : JAD, vol. 77, no. 2, 2020, pp. 781-794.
Zhang C, Luo J, Yuan C, et al. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020;77(2):781-794.
Zhang, C., Luo, J., Yuan, C., & Ding, D. (2020). Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease : JAD, 77(2), 781-794. https://doi.org/10.3233/JAD-200534
Zhang C, et al. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: a Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020;77(2):781-794. PubMed PMID: 32773392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. AU - Zhang,Chenbo, AU - Luo,Jianfeng, AU - Yuan,Changzheng, AU - Ding,Ding, PY - 2020/8/11/pubmed PY - 2021/9/10/medline PY - 2020/8/11/entrez KW - Alzheimer’s disease KW - cognitive decline KW - dementia KW - folate KW - nutrition KW - vitamin B12 KW - vitamin B6 SP - 781 EP - 794 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 77 IS - 2 N2 - BACKGROUND: Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults. OBJECTIVE: To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. METHODS: Medline (PubMed), EMBASE, and Cochrane databases were used to search the literature though August 8, 2019. We included observational population-based studies evaluating the association between concentrations or intake levels of vitamins B6, B12, or folate and cognition in older adults aged ≥45 years. The quality of all studies was assessed by the modified Newcastle-Ottawa Scale. Odds ratios (ORs) and hazard ratios (HRs) were analyzed by the random-effects model. Sensitivity analyses were conducted by excluding the studies with significant heterogeneity. RESULTS: Twenty-one observational studies with sample sizes ranging from 155-7030 were included in the meta-analysis. Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61-0.97) and folate concentration (OR = 0.68, 95% CI = 0.51-0.90) were associated with better cognition in cross-sectional studies, but not in sensitivity analyses or prospective studies. High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk. Prospective studies did not provide substantial evidence for the relationship. CONCLUSION: The results from our meta-analysis suggest that vitamins B12, B6, and folate may not be modifiable risk factors for slowing cognitive decline among community-dwelling older individuals. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/32773392/Vitamin_B12_B6_or_Folate_and_Cognitive_Function_in_Community_Dwelling_Older_Adults:_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -