Tags

Type your tag names separated by a space and hit enter

Inhibition of methacholine-induced bronchoconstriction in patients with chronic obstructive pulmonary disease.
Am Rev Respir Dis. 1988 Feb; 137(2):281-5.AR

Abstract

Patients with COPD have increased airway responsiveness to pharmacologically induced bronchoconstriction when compared with normal healthy subjects. We questioned whether an inhaled bronchodilator such as isoproterenol would benefit patients with COPD by inhibiting inducible bronchoconstriction. Ten patients with COPD were found to be more sensitive to methacholine by inhalation bronchial challenge testing than were normal control subjects. (PD35 = 58 +/- 110 versus 238 +/- 220 cumulative dose units). Neither group as a whole demonstrated significant inhibition of methacholine-induced bronchoconstriction by prior inhalation of isoproterenol (200 micrograms at mouth). However, within the COPD group, there was a significant negative correlation between both baseline lung function and airway responsiveness (PD35-SGaw) with inhibition of methacholine-induced bronchoconstriction. (r = -0.8, p less than or equal to 0.003). This suggests that those patients with COPD and significantly reduced lung function (%FEV1 less than 50%) demonstrate airway hyperresponsiveness to a degree recorded in asthma and may benefit from therapy that inhibits airway responsiveness.

Authors+Show Affiliations

Department of Pulmonary and Critical Care Medicine, Medical College of Pennsylvania, Philadelphia.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3277497

Citation

Greenspon, L W., and B Parrish. "Inhibition of Methacholine-induced Bronchoconstriction in Patients With Chronic Obstructive Pulmonary Disease." The American Review of Respiratory Disease, vol. 137, no. 2, 1988, pp. 281-5.
Greenspon LW, Parrish B. Inhibition of methacholine-induced bronchoconstriction in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1988;137(2):281-5.
Greenspon, L. W., & Parrish, B. (1988). Inhibition of methacholine-induced bronchoconstriction in patients with chronic obstructive pulmonary disease. The American Review of Respiratory Disease, 137(2), 281-5.
Greenspon LW, Parrish B. Inhibition of Methacholine-induced Bronchoconstriction in Patients With Chronic Obstructive Pulmonary Disease. Am Rev Respir Dis. 1988;137(2):281-5. PubMed PMID: 3277497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of methacholine-induced bronchoconstriction in patients with chronic obstructive pulmonary disease. AU - Greenspon,L W, AU - Parrish,B, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 281 EP - 5 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 137 IS - 2 N2 - Patients with COPD have increased airway responsiveness to pharmacologically induced bronchoconstriction when compared with normal healthy subjects. We questioned whether an inhaled bronchodilator such as isoproterenol would benefit patients with COPD by inhibiting inducible bronchoconstriction. Ten patients with COPD were found to be more sensitive to methacholine by inhalation bronchial challenge testing than were normal control subjects. (PD35 = 58 +/- 110 versus 238 +/- 220 cumulative dose units). Neither group as a whole demonstrated significant inhibition of methacholine-induced bronchoconstriction by prior inhalation of isoproterenol (200 micrograms at mouth). However, within the COPD group, there was a significant negative correlation between both baseline lung function and airway responsiveness (PD35-SGaw) with inhibition of methacholine-induced bronchoconstriction. (r = -0.8, p less than or equal to 0.003). This suggests that those patients with COPD and significantly reduced lung function (%FEV1 less than 50%) demonstrate airway hyperresponsiveness to a degree recorded in asthma and may benefit from therapy that inhibits airway responsiveness. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/3277497/Inhibition_of_methacholine_induced_bronchoconstriction_in_patients_with_chronic_obstructive_pulmonary_disease_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/137.2.281?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -