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Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease.
J Trop Pediatr. 2020 Aug 10 [Online ahead of print]JT

Abstract

There have been recent reports of children presenting with severe multi-system hyperinflammatory syndrome resembling Kawasaki disease (KD) during current COVID-19 pandemic. Exact pathophysiology is unknown, however, most of the children have multi-organ dysfunction and respiratory system involvement is less common compared to adults. These patients have certain characteristic laboratory parameters different from those seen in children with KD. However, only limited literature is available at present for identification and management of such patients. We report a young girl who presented with fever, rash and other manifestations mimicking classic KD and fulfilling the case definitions for pediatric multi-system inflammatory syndrome. She had lymphopenia, thrombocytopenia and hyponatremia in the absence of macrophage activation syndrome, similar to that seen in patients reported from UK and Italy. Clinical manifestations resolved and laboratory parameters improved with intravenous immunoglobulin and corticosteroids. Early recognition is important to administer immunomodulatory therapy which may be life saving for these patients.

Authors+Show Affiliations

Department of Pediatric Rheumatology & Immunology, MEDENS Hospital, Panchkula 134113, Haryana, India.Department of Pediatrics and Neonatology, Max Super Speciality Hospital, Mohali 160055, Punjab, India.Department of Pediatrics and Neonatology, Max Super Speciality Hospital, Mohali 160055, Punjab, India.Department of Dermatology & Cosmetology, MEDENS Hospital, Panchkula 134113, Haryana, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32778886

Citation

Gupta, Aman, et al. "Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease." Journal of Tropical Pediatrics, 2020.
Gupta A, Gill A, Sharma M, et al. Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease. J Trop Pediatr. 2020.
Gupta, A., Gill, A., Sharma, M., & Garg, M. (2020). Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease. Journal of Tropical Pediatrics. https://doi.org/10.1093/tropej/fmaa060
Gupta A, et al. Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease. J Trop Pediatr. 2020 Aug 10; PubMed PMID: 32778886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease. AU - Gupta,Aman, AU - Gill,Arpinder, AU - Sharma,Manu, AU - Garg,Megha, Y1 - 2020/08/10/ PY - 2020/8/12/entrez KW - COVID-19 KW - Kawasaki disease KW - MIS-C KW - PIMS JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. N2 - There have been recent reports of children presenting with severe multi-system hyperinflammatory syndrome resembling Kawasaki disease (KD) during current COVID-19 pandemic. Exact pathophysiology is unknown, however, most of the children have multi-organ dysfunction and respiratory system involvement is less common compared to adults. These patients have certain characteristic laboratory parameters different from those seen in children with KD. However, only limited literature is available at present for identification and management of such patients. We report a young girl who presented with fever, rash and other manifestations mimicking classic KD and fulfilling the case definitions for pediatric multi-system inflammatory syndrome. She had lymphopenia, thrombocytopenia and hyponatremia in the absence of macrophage activation syndrome, similar to that seen in patients reported from UK and Italy. Clinical manifestations resolved and laboratory parameters improved with intravenous immunoglobulin and corticosteroids. Early recognition is important to administer immunomodulatory therapy which may be life saving for these patients. SN - 1465-3664 UR - https://www.unboundmedicine.com/medline/citation/32778886/Multi_System_Inflammatory_Syndrome_in_a_Child_Mimicking_Kawasaki_Disease_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmaa060 DB - PRIME DP - Unbound Medicine ER -
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