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Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection.
Urol Int. 2020; 104(9-10):678-683.UI

Abstract

INTRODUCTION

The presence of new coronavirus (SARS-CoV-2) in semen and the possibility of sexual transmission have become new subjects of curiosity. There is a discrepancy regarding this issue in the literature. The presence of SARS-CoV-2 in semen has been investigated in a limited number of studies, and mostly in recovering patients. We aimed to investigate the presence of SARS-CoV-2 RNA in semen of patients with a positive nasopharyngeal swab test for SARS-CoV-2 in the acute stage.

METHODS

We enrolled adult male patients who were hospitalized with confirmed SARS-COV-2 infection in the study. In addition to routine laboratory and radiological tests, semen sample was obtained from volunteers and transferred to the Turkish Public Health Institution, National Virology Laboratory. The samples were processed for the detection of SARS-CoV-2 RNA on the day of collection.

RESULTS

Sixteen patients were included in the study. The median age was 33.5 years (18-54). All but one had respiratory symptoms. None of the patients had a history or symptoms of urogenital disease. All semen samples were obtained during hospitalization and in the acute stage of the infection. The median time to obtain a semen sample after positive nasopharyngeal test was 1 day (0-7). All semen samples were detected as negative for SARS-CoV-2 PCR.

DISCUSSION/CONCLUSION

Although all semen samples were obtained in acute stage of the infection when the nasopharyngeal swab test was positive, we did not detect SARS-CoV-2 in semen. The results of our study support the thought that sexual transmission via semen does not have an important role in the person-to-person transmission of SARS-CoV-2. We think that our study will provide new information to fill the gap in the literature.

Authors+Show Affiliations

Infectious Disease and Clinical Microbiology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey, drbican@gmail.com.Clinical Microbiology, Virology, National Virology Laboratory, Turkish Public Health Institution, Ankara, Turkey.Infectious Disease and Clinical Microbiology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.Infectious Disease and Clinical Microbiology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.Infectious Disease and Clinical Microbiology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.Infectious Disease and Clinical Microbiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.Infectious Disease and Clinical Microbiology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32781456

Citation

Kayaaslan, Bircan, et al. "Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection." Urologia Internationalis, vol. 104, no. 9-10, 2020, pp. 678-683.
Kayaaslan B, Korukluoglu G, Hasanoglu I, et al. Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection. Urol Int. 2020;104(9-10):678-683.
Kayaaslan, B., Korukluoglu, G., Hasanoglu, I., Kalem, A. K., Eser, F., Akinci, E., & Guner, R. (2020). Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection. Urologia Internationalis, 104(9-10), 678-683. https://doi.org/10.1159/000510531
Kayaaslan B, et al. Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection. Urol Int. 2020;104(9-10):678-683. PubMed PMID: 32781456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of SARS-CoV-2 in Semen of Patients in the Acute Stage of COVID-19 Infection. AU - Kayaaslan,Bircan, AU - Korukluoglu,Gulay, AU - Hasanoglu,Imran, AU - Kalem,Ayse Kaya, AU - Eser,Fatma, AU - Akinci,Esragul, AU - Guner,Rahmet, Y1 - 2020/08/11/ PY - 2020/06/23/received PY - 2020/07/27/accepted PY - 2020/8/12/pubmed PY - 2020/9/10/medline PY - 2020/8/12/entrez KW - COVID-19 KW - PCR KW - SARS-CoV-2 KW - Semen KW - Sexual transmission SP - 678 EP - 683 JF - Urologia internationalis JO - Urol Int VL - 104 IS - 9-10 N2 - INTRODUCTION: The presence of new coronavirus (SARS-CoV-2) in semen and the possibility of sexual transmission have become new subjects of curiosity. There is a discrepancy regarding this issue in the literature. The presence of SARS-CoV-2 in semen has been investigated in a limited number of studies, and mostly in recovering patients. We aimed to investigate the presence of SARS-CoV-2 RNA in semen of patients with a positive nasopharyngeal swab test for SARS-CoV-2 in the acute stage. METHODS: We enrolled adult male patients who were hospitalized with confirmed SARS-COV-2 infection in the study. In addition to routine laboratory and radiological tests, semen sample was obtained from volunteers and transferred to the Turkish Public Health Institution, National Virology Laboratory. The samples were processed for the detection of SARS-CoV-2 RNA on the day of collection. RESULTS: Sixteen patients were included in the study. The median age was 33.5 years (18-54). All but one had respiratory symptoms. None of the patients had a history or symptoms of urogenital disease. All semen samples were obtained during hospitalization and in the acute stage of the infection. The median time to obtain a semen sample after positive nasopharyngeal test was 1 day (0-7). All semen samples were detected as negative for SARS-CoV-2 PCR. DISCUSSION/CONCLUSION: Although all semen samples were obtained in acute stage of the infection when the nasopharyngeal swab test was positive, we did not detect SARS-CoV-2 in semen. The results of our study support the thought that sexual transmission via semen does not have an important role in the person-to-person transmission of SARS-CoV-2. We think that our study will provide new information to fill the gap in the literature. SN - 1423-0399 UR - https://www.unboundmedicine.com/medline/citation/32781456/Investigation_of_SARS_CoV_2_in_Semen_of_Patients_in_the_Acute_Stage_of_COVID_19_Infection_ L2 - https://www.karger.com?DOI=10.1159/000510531 DB - PRIME DP - Unbound Medicine ER -