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Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain.
Brain Sci. 2020 Aug 06; 10(8)BS

Abstract

Both opioids and cannabinoids have well-known antinociceptive effects in different animal models of chronic pain. However, unwanted side effects limit their use. The aim of this study is to evaluate the antinociceptive effect of combining synthetic cannabinoids with subtherapeutic doses of opioids, and to evaluate the effects of these drugs/combinations on rat's locomotor activity. Intra-plantar injection of Complete Freund's Adjuvant (CFA) into the left hindpaw and intraperitoneal injection of streptozotocin (STZ) were used to induce inflammatory and diabetic neuropathic pain in adult male Sprague-Dawley rats, respectively. Von Frey filaments were used to assess the antinociceptive effects of opioids (morphine and tramadol) and the synthetic cannabinoids (HU210 and WIN55212) or their combinations on CFA and STZ-induced mechanical allodynia. Open field test was used to evaluate the effect of these drugs or their combinations on locomotion. HU210 and WIN55212 did not produce significant antinociceptive effect on inflammatory pain while only the maximal dose of HU210 (1 mg/kg) was effective in neuropathic pain. Only the maximal doses of morphine (3.2 mg/kg) and tramadol (10 mg/kg) had significant anti-allodynic effects in both models. Tramadol (1 mg/kg) enhanced the antinociceptive effects of WIN55212 but not HU210 in neuropathic pain with no effect on inflammatory pain. However, in open field test, the aforementioned combination did not change tramadol-induced depression of locomotion. Tramadol and WIN55212 combination produces antinociceptive effects in neuropathic but not inflammatory pain at low doses with no additional risk of locomotor impairment, which may be useful in clinical practice.

Authors+Show Affiliations

Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan.Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.Faculty of Science, The University of Jordan, Amman 11942, Jordan.Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32781705

Citation

Alsalem, Mohammad, et al. "Analgesic Effects and Impairment in Locomotor Activity Induced By Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain." Brain Sciences, vol. 10, no. 8, 2020.
Alsalem M, Altarifi A, Haddad M, et al. Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain. Brain sciences. 2020;10(8).
Alsalem, M., Altarifi, A., Haddad, M., Azab, B., Kalbouneh, H., Imraish, A., Saleh, T., & El-Salem, K. (2020). Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain. Brain Sciences, 10(8). https://doi.org/10.3390/brainsci10080523
Alsalem M, et al. Analgesic Effects and Impairment in Locomotor Activity Induced By Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain. Brain sciences. 2020 Aug 6;10(8) PubMed PMID: 32781705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain. AU - Alsalem,Mohammad, AU - Altarifi,Ahmad, AU - Haddad,Mansour, AU - Azab,Belal, AU - Kalbouneh,Heba, AU - Imraish,Amer, AU - Saleh,Tareq, AU - El-Salem,Khalid, Y1 - 2020/08/06/ PY - 2020/07/10/received PY - 2020/08/02/revised PY - 2020/08/03/accepted PY - 2020/8/13/entrez PY - 2020/8/13/pubmed PY - 2020/8/13/medline KW - Complete Freund’s Adjuvant (CFA) KW - HU210 KW - WIN55212 KW - chronic pain KW - morphine KW - open field test KW - streptozotocin (STZ) KW - tramadol KW - von Frey filament test JF - Brain sciences VL - 10 IS - 8 N2 - Both opioids and cannabinoids have well-known antinociceptive effects in different animal models of chronic pain. However, unwanted side effects limit their use. The aim of this study is to evaluate the antinociceptive effect of combining synthetic cannabinoids with subtherapeutic doses of opioids, and to evaluate the effects of these drugs/combinations on rat's locomotor activity. Intra-plantar injection of Complete Freund's Adjuvant (CFA) into the left hindpaw and intraperitoneal injection of streptozotocin (STZ) were used to induce inflammatory and diabetic neuropathic pain in adult male Sprague-Dawley rats, respectively. Von Frey filaments were used to assess the antinociceptive effects of opioids (morphine and tramadol) and the synthetic cannabinoids (HU210 and WIN55212) or their combinations on CFA and STZ-induced mechanical allodynia. Open field test was used to evaluate the effect of these drugs or their combinations on locomotion. HU210 and WIN55212 did not produce significant antinociceptive effect on inflammatory pain while only the maximal dose of HU210 (1 mg/kg) was effective in neuropathic pain. Only the maximal doses of morphine (3.2 mg/kg) and tramadol (10 mg/kg) had significant anti-allodynic effects in both models. Tramadol (1 mg/kg) enhanced the antinociceptive effects of WIN55212 but not HU210 in neuropathic pain with no effect on inflammatory pain. However, in open field test, the aforementioned combination did not change tramadol-induced depression of locomotion. Tramadol and WIN55212 combination produces antinociceptive effects in neuropathic but not inflammatory pain at low doses with no additional risk of locomotor impairment, which may be useful in clinical practice. SN - 2076-3425 UR - https://www.unboundmedicine.com/medline/citation/32781705/Analgesic_Effects_and_Impairment_in_Locomotor_Activity_Induced_by_Cannabinoid/Opioid_Combinations_in_Rat_Models_of_Chronic_Pain_ L2 - https://www.mdpi.com/resolver?pii=brainsci10080523 DB - PRIME DP - Unbound Medicine ER -
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