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Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19.
Nutrients. 2020 Aug 07; 12(8)N

Abstract

OBJECTIVES

The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19.

METHODS

We conducted an online search for articles published in the period 2010-2020 on zinc, selenium, and vitamin D, and corona and related virus infections.

RESULTS

There were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19.

CONCLUSION

We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.

Links

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Authors+Show Affiliations

Alexander J
Division of Infection Control and Environment Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, 0213 Oslo, Norway.
Tinkov A
Laboratory of Biotechnology and Bioelementology, Yaroslavl State University, Sovetskaya Str. 14, Yaroslavl 150000, Russia. IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., Moscow 119146, Russia.
Strand TA
Centre for International Health, University of Bergen, P.O. Box 7804, 5020 Bergen, Norway. Research Department, Innlandet Hospital Trust, P.O. Box 104, 2381 Brumunddal, Norway.
Alehagen U
Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, SE-58185 Linköping, Sweden.
Skalny A
Laboratory of Biotechnology and Bioelementology, Yaroslavl State University, Sovetskaya Str. 14, Yaroslavl 150000, Russia. IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., Moscow 119146, Russia.
Aaseth J
IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., Moscow 119146, Russia. Research Department, Innlandet Hospital Trust, P.O. Box 104, 2381 Brumunddal, Norway.

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsDeficiency DiseasesDisease ProgressionFemaleHumansInflammationMaleMicronutrientsNutritional StatusPandemicsPneumonia, ViralSARS-CoV-2SeleniumVitamin DZinc

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32784601

Citation

Alexander, Jan, et al. "Early Nutritional Interventions With Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19." Nutrients, vol. 12, no. 8, 2020.
Alexander J, Tinkov A, Strand TA, et al. Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. Nutrients. 2020;12(8).
Alexander, J., Tinkov, A., Strand, T. A., Alehagen, U., Skalny, A., & Aaseth, J. (2020). Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. Nutrients, 12(8). https://doi.org/10.3390/nu12082358
Alexander J, et al. Early Nutritional Interventions With Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. Nutrients. 2020 Aug 7;12(8) PubMed PMID: 32784601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. AU - Alexander,Jan, AU - Tinkov,Alexey, AU - Strand,Tor A, AU - Alehagen,Urban, AU - Skalny,Anatoly, AU - Aaseth,Jan, Y1 - 2020/08/07/ PY - 2020/07/16/received PY - 2020/08/04/revised PY - 2020/08/05/accepted PY - 2020/8/14/entrez PY - 2020/8/14/pubmed PY - 2020/8/26/medline KW - COVID-19 KW - coenzyme Q10 KW - corona virus KW - micronutrients KW - nutritional KW - selenium KW - therapy KW - vitamin A KW - vitamin D KW - zinc JF - Nutrients JO - Nutrients VL - 12 IS - 8 N2 - OBJECTIVES: The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19. METHODS: We conducted an online search for articles published in the period 2010-2020 on zinc, selenium, and vitamin D, and corona and related virus infections. RESULTS: There were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19. CONCLUSION: We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32784601/Early_Nutritional_Interventions_with_Zinc_Selenium_and_Vitamin_D_for_Raising_Anti_Viral_Resistance_Against_Progressive_COVID_19_ DB - PRIME DP - Unbound Medicine ER -