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Vaccine Candidates against Coronavirus Infections. Where Does COVID-19 Stand?
Viruses. 2020 08 07; 12(8)V

Abstract

Seven years after the Middle East respiratory syndrome (MERS) outbreak, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) made its first appearance in a food market in Wuhan, China, drawing an entirely new course to our lives. As the virus belongs to the same genus of MERS and SARS, researchers have been trying to draw lessons from previous outbreaks to find a potential cure. Although there were five Phase I human vaccine trials against SARS and MERS, the lack of data in humans provided us with limited benchmarks that could help us design a new vaccine for Coronavirus disease 2019 (COVID-19). In this review, we showcase the similarities in structures of virus components between SARS-CoV, MERS-CoV, and SARS-CoV-2 in areas relevant to vaccine design. Using the ClinicalTrials.gov and World Health Organization (WHO) databases, we shed light on the 16 current approved clinical trials worldwide in search for a COVID-19 vaccine. The different vaccine platforms being tested are Bacillus Calmette-Guérin (BCG) vaccines, DNA and RNA-based vaccines, inactivated vaccines, protein subunits, and viral vectors. By thoroughly analyzing different trials and platforms, we also discuss the advantages and disadvantages of using each type of vaccine and how they can contribute to the design of an adequate vaccine for COVID-19. Studying past efforts invested in conducting vaccine trials for MERS and SARS will provide vital insights regarding the best approach to designing an effective vaccine against COVID-19.

Authors+Show Affiliations

Department of Experimental Surgery, McGill University, Montreal General Hospital 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada.Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1V 4G2, Canada.Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1V 4G2, Canada. Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada. Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4238, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32784685

Citation

Al-Kassmy, Jawad, et al. "Vaccine Candidates Against Coronavirus Infections. Where Does COVID-19 Stand?" Viruses, vol. 12, no. 8, 2020.
Al-Kassmy J, Pedersen J, Kobinger G. Vaccine Candidates against Coronavirus Infections. Where Does COVID-19 Stand? Viruses. 2020;12(8).
Al-Kassmy, J., Pedersen, J., & Kobinger, G. (2020). Vaccine Candidates against Coronavirus Infections. Where Does COVID-19 Stand? Viruses, 12(8). https://doi.org/10.3390/v12080861
Al-Kassmy J, Pedersen J, Kobinger G. Vaccine Candidates Against Coronavirus Infections. Where Does COVID-19 Stand. Viruses. 2020 08 7;12(8) PubMed PMID: 32784685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccine Candidates against Coronavirus Infections. Where Does COVID-19 Stand? AU - Al-Kassmy,Jawad, AU - Pedersen,Jannie, AU - Kobinger,Gary, Y1 - 2020/08/07/ PY - 2020/07/11/received PY - 2020/08/03/revised PY - 2020/08/05/accepted PY - 2020/8/14/entrez PY - 2020/8/14/pubmed PY - 2020/9/10/medline KW - COVID-19 KW - MERS KW - SARS KW - clinical trials KW - coronavirus KW - vaccine JF - Viruses JO - Viruses VL - 12 IS - 8 N2 - Seven years after the Middle East respiratory syndrome (MERS) outbreak, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) made its first appearance in a food market in Wuhan, China, drawing an entirely new course to our lives. As the virus belongs to the same genus of MERS and SARS, researchers have been trying to draw lessons from previous outbreaks to find a potential cure. Although there were five Phase I human vaccine trials against SARS and MERS, the lack of data in humans provided us with limited benchmarks that could help us design a new vaccine for Coronavirus disease 2019 (COVID-19). In this review, we showcase the similarities in structures of virus components between SARS-CoV, MERS-CoV, and SARS-CoV-2 in areas relevant to vaccine design. Using the ClinicalTrials.gov and World Health Organization (WHO) databases, we shed light on the 16 current approved clinical trials worldwide in search for a COVID-19 vaccine. The different vaccine platforms being tested are Bacillus Calmette-Guérin (BCG) vaccines, DNA and RNA-based vaccines, inactivated vaccines, protein subunits, and viral vectors. By thoroughly analyzing different trials and platforms, we also discuss the advantages and disadvantages of using each type of vaccine and how they can contribute to the design of an adequate vaccine for COVID-19. Studying past efforts invested in conducting vaccine trials for MERS and SARS will provide vital insights regarding the best approach to designing an effective vaccine against COVID-19. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/32784685/Vaccine_Candidates_against_Coronavirus_Infections__Where_Does_COVID_19_Stand L2 - https://www.mdpi.com/resolver?pii=v12080861 DB - PRIME DP - Unbound Medicine ER -