Tags

Type your tag names separated by a space and hit enter

Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6.
ACS Chem Neurosci. 2020 09 02; 11(17):2774-2781.AC

Abstract

The rapid recovery of smell and taste functions in COVID-19 patients could be attributed to a decrease in interleukin-6 levels rather than central nervous system ischemic injury or viral damage to neuronal cells. To correlate interleukin-6 levels in COVID-19 patients with olfactory or gustatory dysfunctions and to investigate the role of IL-6 in the onset of these disorders, this observational study investigated 67 COVID-19 patients with taste or smell disorders or both, who did not require intensive care admission, admitted at COVID Hospital of Policlinico of Bari from March to May 2020. Interleukin-6 was assayed in COVID-19 patients with taste or smell disturbances at the time of admission and at the time of swab negativization. At the same time, patients have been given a specific survey to evaluate the severity of taste and smell disturbances. Of 125 patients with smell or taste dysfunctions at onset of disease, 67 fulfilled the inclusion criteria, while 58 were excluded because 35 of them required intensive care admission, 5 were unable to answer, 5 died, 7 had finished chemotherapy recently, and 5 refused to participate. The evaluation of taste and smell disorders was carried out using a survey performed at the time of admission and at the time of swab negativization. Sinonasal outcome test 22 (SNOT-22) was used as a reference for olfactory function assessment, and Taste and Smell Questionnaire Section of the US NHANES 2011-2014 protocol (CDC 2013b) was used as reference for gustatory function assessment. A venous blood sample was taken for each patient to measure IL-6 levels upon entry and at swab negativization. Interleukin-6 levels in COVID-19 patients in relation to olfactory or gustatory disorders were correlated from the time of their admission to the time of swab negativization. Statistically significant correlations were obtained between the decrease of interleukin-6 levels and the improvement of smell (p value < 0.05) and taste (p = 0.047) functions at swab negativization. The acquired results demonstrate the key role of interleukin-6 in the pathogenesis of chemosensitive disorders in COVID-19 patients.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.Private practice, Bari 70124, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Emergency Medicine and Surgery Unit, Bari 70124, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Emergency Medicine and Surgery Unit, Bari 70124, Italy.Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Human Anatomy Section, Università degli Studi di Bari, Bari 70124, Italy.Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.Maugeri Clinical Research Institutes IRCCS of Bari, Bari 70124, Italy.Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Human Anatomy Section, Università degli Studi di Bari, Bari 70124, Italy.AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.Ionian Department (DJSGEM), Microbiology and Virology Lab, Università degli Studi di Bari, Bari 70124, Italy.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32786309

Citation

Cazzolla, Angela P., et al. "Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6." ACS Chemical Neuroscience, vol. 11, no. 17, 2020, pp. 2774-2781.
Cazzolla AP, Lovero R, Lo Muzio L, et al. Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6. ACS Chem Neurosci. 2020;11(17):2774-2781.
Cazzolla, A. P., Lovero, R., Lo Muzio, L., Testa, N. F., Schirinzi, A., Palmieri, G., Pozzessere, P., Procacci, V., Di Comite, M., Ciavarella, D., Pepe, M., De Ruvo, C., Crincoli, V., Di Serio, F., & Santacroce, L. (2020). Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6. ACS Chemical Neuroscience, 11(17), 2774-2781. https://doi.org/10.1021/acschemneuro.0c00447
Cazzolla AP, et al. Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6. ACS Chem Neurosci. 2020 09 2;11(17):2774-2781. PubMed PMID: 32786309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6. AU - Cazzolla,Angela P, AU - Lovero,Roberto, AU - Lo Muzio,Lorenzo, AU - Testa,Nunzio F, AU - Schirinzi,Annalisa, AU - Palmieri,Giuseppe, AU - Pozzessere,Pietro, AU - Procacci,Vito, AU - Di Comite,Mariasevera, AU - Ciavarella,Domenico, AU - Pepe,Maria, AU - De Ruvo,Caterina, AU - Crincoli,Vito, AU - Di Serio,Francesca, AU - Santacroce,Luigi, Y1 - 2020/08/19/ PY - 2020/8/14/pubmed PY - 2020/9/17/medline PY - 2020/8/14/entrez KW - COVID-19 KW - SARS-CoV-2 KW - anosmia KW - dysgeusia KW - immune-mediated neurological syndromes KW - interleukin-6 (IL-6) SP - 2774 EP - 2781 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 11 IS - 17 N2 - The rapid recovery of smell and taste functions in COVID-19 patients could be attributed to a decrease in interleukin-6 levels rather than central nervous system ischemic injury or viral damage to neuronal cells. To correlate interleukin-6 levels in COVID-19 patients with olfactory or gustatory dysfunctions and to investigate the role of IL-6 in the onset of these disorders, this observational study investigated 67 COVID-19 patients with taste or smell disorders or both, who did not require intensive care admission, admitted at COVID Hospital of Policlinico of Bari from March to May 2020. Interleukin-6 was assayed in COVID-19 patients with taste or smell disturbances at the time of admission and at the time of swab negativization. At the same time, patients have been given a specific survey to evaluate the severity of taste and smell disturbances. Of 125 patients with smell or taste dysfunctions at onset of disease, 67 fulfilled the inclusion criteria, while 58 were excluded because 35 of them required intensive care admission, 5 were unable to answer, 5 died, 7 had finished chemotherapy recently, and 5 refused to participate. The evaluation of taste and smell disorders was carried out using a survey performed at the time of admission and at the time of swab negativization. Sinonasal outcome test 22 (SNOT-22) was used as a reference for olfactory function assessment, and Taste and Smell Questionnaire Section of the US NHANES 2011-2014 protocol (CDC 2013b) was used as reference for gustatory function assessment. A venous blood sample was taken for each patient to measure IL-6 levels upon entry and at swab negativization. Interleukin-6 levels in COVID-19 patients in relation to olfactory or gustatory disorders were correlated from the time of their admission to the time of swab negativization. Statistically significant correlations were obtained between the decrease of interleukin-6 levels and the improvement of smell (p value < 0.05) and taste (p = 0.047) functions at swab negativization. The acquired results demonstrate the key role of interleukin-6 in the pathogenesis of chemosensitive disorders in COVID-19 patients. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/32786309/Taste_and_Smell_Disorders_in_COVID_19_Patients:_Role_of_Interleukin_6_ L2 - https://doi.org/10.1021/acschemneuro.0c00447 DB - PRIME DP - Unbound Medicine ER -