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Autologous red blood cell reinfusion: effects on stress and fluid regulatory hormones during exercise in the heat.
Aviat Space Environ Med. 1988 Feb; 59(2):133-7.AS

Abstract

This study assessed the effects of induced erythrocythemia on stress and fluid regulatory hormones during walking exercise in the heat. Six unacclimated male subjects received approximately 600 ml of a sterile saline solution containing 50% volume-to-volume of autologous erythrocytes. Three heat stress tests (HSTs) were attempted: one approximately 2 weeks prior to the reinfusion procedure, a second 48 h after the reinfusion procedure, and a third 1 week later, corresponding to 9 d subsequent to reinfusion. Each HST comprised three consecutive 45-min exercise and 15-min rest intervals (VO2 approximately 2.0 L.min-1, 1.56 m.s-1, 6% incline, 35 degrees C, 45% rh). Blood was withdrawn before the HST and 30 min into each exercise (EX) bout. In all three HST's plasma cortisol (PC) levels were significantly (p less than 0.01) reduced during the first EX bout compared to preexercise levels, and then progressively increased during the second and third EX intervals during HST 1. During HST 2 (48 h postinfusion), however, PC levels were significantly (p less than 0.05) reduced in two blood samples (EX 2, 3) compared to the same blood samples from HST-1 (preinfusion). Plasma renin activity (PRA) and aldosterone (ALD) were significantly (p less than 0.01) increased by the exercise/heat stress, but were unaffected by erythrocythemia either 48 h or 9 d subsequent to reinfusion. PRA and ALD were correlated (r = 0.84, p less than 0.001) under all conditions. We concluded from this study that acutely induced erythrocythemia reduced the stress response to consecutive exercise/heat intervals as manifested in PC responses during HST 2.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760-5007.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3278708

Citation

Francesconi, R P., et al. "Autologous Red Blood Cell Reinfusion: Effects On Stress and Fluid Regulatory Hormones During Exercise in the Heat." Aviation, Space, and Environmental Medicine, vol. 59, no. 2, 1988, pp. 133-7.
Francesconi RP, Sawka MN, Dennis RC, et al. Autologous red blood cell reinfusion: effects on stress and fluid regulatory hormones during exercise in the heat. Aviat Space Environ Med. 1988;59(2):133-7.
Francesconi, R. P., Sawka, M. N., Dennis, R. C., Gonzalez, R. R., Young, A. J., & Valeri, C. R. (1988). Autologous red blood cell reinfusion: effects on stress and fluid regulatory hormones during exercise in the heat. Aviation, Space, and Environmental Medicine, 59(2), 133-7.
Francesconi RP, et al. Autologous Red Blood Cell Reinfusion: Effects On Stress and Fluid Regulatory Hormones During Exercise in the Heat. Aviat Space Environ Med. 1988;59(2):133-7. PubMed PMID: 3278708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autologous red blood cell reinfusion: effects on stress and fluid regulatory hormones during exercise in the heat. AU - Francesconi,R P, AU - Sawka,M N, AU - Dennis,R C, AU - Gonzalez,R R, AU - Young,A J, AU - Valeri,C R, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 133 EP - 7 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 59 IS - 2 N2 - This study assessed the effects of induced erythrocythemia on stress and fluid regulatory hormones during walking exercise in the heat. Six unacclimated male subjects received approximately 600 ml of a sterile saline solution containing 50% volume-to-volume of autologous erythrocytes. Three heat stress tests (HSTs) were attempted: one approximately 2 weeks prior to the reinfusion procedure, a second 48 h after the reinfusion procedure, and a third 1 week later, corresponding to 9 d subsequent to reinfusion. Each HST comprised three consecutive 45-min exercise and 15-min rest intervals (VO2 approximately 2.0 L.min-1, 1.56 m.s-1, 6% incline, 35 degrees C, 45% rh). Blood was withdrawn before the HST and 30 min into each exercise (EX) bout. In all three HST's plasma cortisol (PC) levels were significantly (p less than 0.01) reduced during the first EX bout compared to preexercise levels, and then progressively increased during the second and third EX intervals during HST 1. During HST 2 (48 h postinfusion), however, PC levels were significantly (p less than 0.05) reduced in two blood samples (EX 2, 3) compared to the same blood samples from HST-1 (preinfusion). Plasma renin activity (PRA) and aldosterone (ALD) were significantly (p less than 0.01) increased by the exercise/heat stress, but were unaffected by erythrocythemia either 48 h or 9 d subsequent to reinfusion. PRA and ALD were correlated (r = 0.84, p less than 0.001) under all conditions. We concluded from this study that acutely induced erythrocythemia reduced the stress response to consecutive exercise/heat intervals as manifested in PC responses during HST 2.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/3278708/Autologous_red_blood_cell_reinfusion:_effects_on_stress_and_fluid_regulatory_hormones_during_exercise_in_the_heat_ L2 - https://antibodies.cancer.gov/detail/CPTC-Calcyclin-1 DB - PRIME DP - Unbound Medicine ER -