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A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient.
Am J Perinatol. 2020 10; 37(12):1280-1282.AJ

Abstract

INTRODUCTION

Data regarding transplacental passage of maternal coronavirus disease 2019 (COVID-19) antibodies and potential immunity in the newborn is limited.

CASE REPORT

We present a 25-year-old multigravida with known red blood cell isoimmunization, who was found to be COVID-19 positive at 27 weeks of gestation while undergoing serial periumbilical blood sampling and intrauterine transfusions. Maternal COVID-19 antibody was detected 2 weeks after positive molecular testing. Antibodies were never detected on cord blood samples from two intrauterine fetal cord blood samples as well as neonatal cord blood at the time of delivery.

CONCLUSION

This case demonstrates a lack of passive immunity of COVID-19 antibodies from a positive pregnant woman to her fetus, neither in utero nor at the time of birth. Further studies are needed to understand if passage of antibodies can occur and if that can confer passive immunity in the newborn.

KEY POINTS

· Passive immunity should not be assumed in COVID-19 infection in pregnancy.. · Isoimmunization may impair passive immunity of certain antibodies.. · Vaccination to or maternal infection of COVID-19 may not be protective for the fetus..

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Authors+Show Affiliations

Toner LE
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Gelber SE
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
Pena JA
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Fox NS
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
Rebarber A
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

MeSH

AdultAnemiaAntibodies, ViralBetacoronavirusBlood Group IncompatibilityBlood Transfusion, IntrauterineCOVID-19COVID-19 TestingClinical Laboratory TechniquesCoronavirus InfectionsFemaleFetal BloodHumansImmunity, Maternally-AcquiredImmunoglobulin GPandemicsPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy Trimester, SecondSARS-CoV-2

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32791537

Citation

Toner, Lorraine E., et al. "A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient." American Journal of Perinatology, vol. 37, no. 12, 2020, pp. 1280-1282.
Toner LE, Gelber SE, Pena JA, et al. A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient. Am J Perinatol. 2020;37(12):1280-1282.
Toner, L. E., Gelber, S. E., Pena, J. A., Fox, N. S., & Rebarber, A. (2020). A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient. American Journal of Perinatology, 37(12), 1280-1282. https://doi.org/10.1055/s-0040-1715643
Toner LE, et al. A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient. Am J Perinatol. 2020;37(12):1280-1282. PubMed PMID: 32791537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient. AU - Toner,Lorraine E, AU - Gelber,Shari E, AU - Pena,Juan A, AU - Fox,Nathan S, AU - Rebarber,Andrei, Y1 - 2020/08/13/ PY - 2020/8/14/pubmed PY - 2020/10/21/medline PY - 2020/8/14/entrez SP - 1280 EP - 1282 JF - American journal of perinatology JO - Am J Perinatol VL - 37 IS - 12 N2 - INTRODUCTION: Data regarding transplacental passage of maternal coronavirus disease 2019 (COVID-19) antibodies and potential immunity in the newborn is limited. CASE REPORT: We present a 25-year-old multigravida with known red blood cell isoimmunization, who was found to be COVID-19 positive at 27 weeks of gestation while undergoing serial periumbilical blood sampling and intrauterine transfusions. Maternal COVID-19 antibody was detected 2 weeks after positive molecular testing. Antibodies were never detected on cord blood samples from two intrauterine fetal cord blood samples as well as neonatal cord blood at the time of delivery. CONCLUSION: This case demonstrates a lack of passive immunity of COVID-19 antibodies from a positive pregnant woman to her fetus, neither in utero nor at the time of birth. Further studies are needed to understand if passage of antibodies can occur and if that can confer passive immunity in the newborn. KEY POINTS: · Passive immunity should not be assumed in COVID-19 infection in pregnancy.. · Isoimmunization may impair passive immunity of certain antibodies.. · Vaccination to or maternal infection of COVID-19 may not be protective for the fetus.. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/32791537/A_Case_Report_to_Assess_Passive_Immunity_in_a_COVID_Positive_Pregnant_Patient_ DB - PRIME DP - Unbound Medicine ER -