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Analysis of ultrafiltration and mass transfer in a bioartificial pancreas.
J Biomech Eng. 1988 Feb; 110(1):1-10.JB

Abstract

A bioartificial pancreas is an implantable device which contains insulin secreting cells (Langerhans islets), separated from the circulating blood by a semi-permeable membrane to avoid rejection. This paper describes the operation of such a device and evaluates the respective contributions of diffusion and ultrafiltration to the glucose and insulin mass transfer. It is shown that the pressure drop along the blood channel produces across the first half of the channel an ultrafiltration flux toward the islet compartment followed in the second half by an equal flux in reverse direction from islets to blood. The mass transfer analysis is carried out for an optimal geometry in which a U-shaped blood channel surrounds closely a very thin islet compartment formed by a folded flat membrane. A complete model of insulin release by this device is developed and is compared with in vitro data obtained with rats islets. Satisfactory kinetics is achieved with a polyacrylonitrile membrane used in hemodialysis. But the model shows that the membrane hydraulic permeability should be increased by a factor of 10 to significantly improve the performance.

Authors+Show Affiliations

Département de Génie Biologique, Université de Technologie de Compiègne, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3279268

Citation

Jaffrin, M Y., et al. "Analysis of Ultrafiltration and Mass Transfer in a Bioartificial Pancreas." Journal of Biomechanical Engineering, vol. 110, no. 1, 1988, pp. 1-10.
Jaffrin MY, Reach G, Notelet D. Analysis of ultrafiltration and mass transfer in a bioartificial pancreas. J Biomech Eng. 1988;110(1):1-10.
Jaffrin, M. Y., Reach, G., & Notelet, D. (1988). Analysis of ultrafiltration and mass transfer in a bioartificial pancreas. Journal of Biomechanical Engineering, 110(1), 1-10.
Jaffrin MY, Reach G, Notelet D. Analysis of Ultrafiltration and Mass Transfer in a Bioartificial Pancreas. J Biomech Eng. 1988;110(1):1-10. PubMed PMID: 3279268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of ultrafiltration and mass transfer in a bioartificial pancreas. AU - Jaffrin,M Y, AU - Reach,G, AU - Notelet,D, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 1 EP - 10 JF - Journal of biomechanical engineering JO - J Biomech Eng VL - 110 IS - 1 N2 - A bioartificial pancreas is an implantable device which contains insulin secreting cells (Langerhans islets), separated from the circulating blood by a semi-permeable membrane to avoid rejection. This paper describes the operation of such a device and evaluates the respective contributions of diffusion and ultrafiltration to the glucose and insulin mass transfer. It is shown that the pressure drop along the blood channel produces across the first half of the channel an ultrafiltration flux toward the islet compartment followed in the second half by an equal flux in reverse direction from islets to blood. The mass transfer analysis is carried out for an optimal geometry in which a U-shaped blood channel surrounds closely a very thin islet compartment formed by a folded flat membrane. A complete model of insulin release by this device is developed and is compared with in vitro data obtained with rats islets. Satisfactory kinetics is achieved with a polyacrylonitrile membrane used in hemodialysis. But the model shows that the membrane hydraulic permeability should be increased by a factor of 10 to significantly improve the performance. SN - 0148-0731 UR - https://www.unboundmedicine.com/medline/citation/3279268/Analysis_of_ultrafiltration_and_mass_transfer_in_a_bioartificial_pancreas_ L2 - https://asmedigitalcollection.asme.org/biomechanical/article-lookup/doi/10.1115/1.3108400 DB - PRIME DP - Unbound Medicine ER -