Approaches and Challenges in SARS-CoV-2 Vaccine Development.Cell Host Microbe. 2020 Sep 09; 28(3):364-370.CH
Abstract
The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Language
eng
PubMed ID
32798444
Clinical Trial Links
Citation
Dagotto, Gabriel, et al. "Approaches and Challenges in SARS-CoV-2 Vaccine Development." Cell Host & Microbe, vol. 28, no. 3, 2020, pp. 364-370.
Dagotto G, Yu J, Barouch DH. Approaches and Challenges in SARS-CoV-2 Vaccine Development. Cell Host Microbe. 2020;28(3):364-370.
Dagotto, G., Yu, J., & Barouch, D. H. (2020). Approaches and Challenges in SARS-CoV-2 Vaccine Development. Cell Host & Microbe, 28(3), 364-370. https://doi.org/10.1016/j.chom.2020.08.002
Dagotto G, Yu J, Barouch DH. Approaches and Challenges in SARS-CoV-2 Vaccine Development. Cell Host Microbe. 2020 Sep 9;28(3):364-370. PubMed PMID: 32798444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Approaches and Challenges in SARS-CoV-2 Vaccine Development.
AU - Dagotto,Gabriel,
AU - Yu,Jingyou,
AU - Barouch,Dan H,
Y1 - 2020/08/10/
PY - 2020/6/9/received
PY - 2020/8/4/revised
PY - 2020/8/5/accepted
PY - 2020/8/18/pubmed
PY - 2020/9/22/medline
PY - 2020/8/18/entrez
KW - COVID-19
KW - SARS-CoV-2
KW - vaccine
SP - 364
EP - 370
JF - Cell host & microbe
JO - Cell Host Microbe
VL - 28
IS - 3
N2 - The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.
SN - 1934-6069
UR - https://www.unboundmedicine.com/medline/citation/32798444/Approaches_and_Challenges_in_SARS_CoV_2_Vaccine_Development_
DB - PRIME
DP - Unbound Medicine
ER -