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Relationship between postsurgical fibrinolytic parameters and deep vein thrombosis in surgical patients treated with compression devices.
Am Surg. 1988 Mar; 54(3):156-60.AS

Abstract

This study consisted of 52 patients admitted for orthopedic surgery and 28 patients admitted for general surgery, who were treated with Sequential Compression Devices (SCD) and Thromboembolic Deterrent Stockings (TEDS) and monitored for the development of deep vein thrombosis (DVT). Coagulation and fibrinolytic profiles were carried out on these patients preoperatively, and on days one, three, and six postoperatively. All patients were followed by I-125-Fibrinogen scanning, Venous Doppler, and Impedance Plethysmography studies for clot detection. In the orthopedic surgery group, six (11.5%) developed DVT, and in the general surgery group, one (3.6%) developed DVT. No patients developed pulmonary embolism. The combined incidence of DVT was 8.8 per cent. A variety of parameters was measured in order to determine whether compression devices prevent a fibrinolytic shut-down commonly seen in the postsurgical patient. A combination of three assays was found to be significant in demonstrating a fibrinolytic response. These parameters were a post-surgical decrease in the plasminogen level, an increase in the level of free protease activity postoperatively, and an increase in the level of tissue plasminogen activator after surgery. 56.3 per cent of all patients treated with SCD and TEDS showed a fibrinolytic response on postoperative day one by a combination of all three of these parameters. In the group of patients that developed DVT none showed an increase in free protease activity, and five of seven showed no significant decrease in plasminogen and no increase in tissue plasminogen activator. Patients who developed thrombosis had measurable differences in their fibrinolytic system compared to those without postoperative thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Surgery, Evanston Hospital, Illinois 60201.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3279880

Citation

Summaria, L, et al. "Relationship Between Postsurgical Fibrinolytic Parameters and Deep Vein Thrombosis in Surgical Patients Treated With Compression Devices." The American Surgeon, vol. 54, no. 3, 1988, pp. 156-60.
Summaria L, Caprini JA, McMillan R, et al. Relationship between postsurgical fibrinolytic parameters and deep vein thrombosis in surgical patients treated with compression devices. Am Surg. 1988;54(3):156-60.
Summaria, L., Caprini, J. A., McMillan, R., Sandesara, J., Axelrod, C. A., Mueller, M. E., Vagher, J. P., Walenga, J., & Fareed, J. (1988). Relationship between postsurgical fibrinolytic parameters and deep vein thrombosis in surgical patients treated with compression devices. The American Surgeon, 54(3), 156-60.
Summaria L, et al. Relationship Between Postsurgical Fibrinolytic Parameters and Deep Vein Thrombosis in Surgical Patients Treated With Compression Devices. Am Surg. 1988;54(3):156-60. PubMed PMID: 3279880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between postsurgical fibrinolytic parameters and deep vein thrombosis in surgical patients treated with compression devices. AU - Summaria,L, AU - Caprini,J A, AU - McMillan,R, AU - Sandesara,J, AU - Axelrod,C A, AU - Mueller,M E, AU - Vagher,J P, AU - Walenga,J, AU - Fareed,J, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 156 EP - 60 JF - The American surgeon JO - Am Surg VL - 54 IS - 3 N2 - This study consisted of 52 patients admitted for orthopedic surgery and 28 patients admitted for general surgery, who were treated with Sequential Compression Devices (SCD) and Thromboembolic Deterrent Stockings (TEDS) and monitored for the development of deep vein thrombosis (DVT). Coagulation and fibrinolytic profiles were carried out on these patients preoperatively, and on days one, three, and six postoperatively. All patients were followed by I-125-Fibrinogen scanning, Venous Doppler, and Impedance Plethysmography studies for clot detection. In the orthopedic surgery group, six (11.5%) developed DVT, and in the general surgery group, one (3.6%) developed DVT. No patients developed pulmonary embolism. The combined incidence of DVT was 8.8 per cent. A variety of parameters was measured in order to determine whether compression devices prevent a fibrinolytic shut-down commonly seen in the postsurgical patient. A combination of three assays was found to be significant in demonstrating a fibrinolytic response. These parameters were a post-surgical decrease in the plasminogen level, an increase in the level of free protease activity postoperatively, and an increase in the level of tissue plasminogen activator after surgery. 56.3 per cent of all patients treated with SCD and TEDS showed a fibrinolytic response on postoperative day one by a combination of all three of these parameters. In the group of patients that developed DVT none showed an increase in free protease activity, and five of seven showed no significant decrease in plasminogen and no increase in tissue plasminogen activator. Patients who developed thrombosis had measurable differences in their fibrinolytic system compared to those without postoperative thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-1348 UR - https://www.unboundmedicine.com/medline/citation/3279880/Relationship_between_postsurgical_fibrinolytic_parameters_and_deep_vein_thrombosis_in_surgical_patients_treated_with_compression_devices_ L2 - https://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -