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Investigation of a family cluster outbreak of COVID-19 indicates the necessity of CT screening for asymptomatic family members in close contact with confirmed patients.
J Thorac Dis. 2020 Jul; 12(7):3673-3681.JT

Abstract

Background

To investigate whether asymptomatic close-contact family members of patients diagnosed with coronavirus disease (COVID-19) should immediately undergo CT screening in addition to the viral nucleic acid test.

Methods

We retrospectively analyzed the data of a family cluster of 8 individuals, of whom 1 family member (Patient 3) had an epidemiologic history of having visited Guangzhou from Hubei Province on January 20, 2020. Her father (Patient 1) developed a fever and respiratory system symptoms and was confirmed COVID-19-positive on February 4-5, 2020 at Zengcheng People's Hospital, Guangzhou, China. Seven close-contact family members of the patients were then screened for COVID-19 on February 5-6 at the hospital. The CT imaging manifestation and laboratory tests of this family cluster were investigated and reported.

Results

Five (62.5%) of the 8 family members were confirmed COVID-19-positive. Except for Patient 1, who had fever, cough, fatigue, and dizziness, the remaining four (4/5, 80%) COVID-19-positive family members (Patients 2-5) had no clinical symptoms. Among the 5 patients, 2 had leukopenia (2/5, 40%), 1 had low absolute neutrophil counts (1/5, 20%), and 2 had increased high-sensitivity C-reactive protein (2/5, 40%). Ground-glass opacity (GGO) was found on chest CT imaging in all 5 patients (5/5, 100%), with interlobular septal thickening. Thickened blood vessel shadows were seen in 3 patients (3/5, 60%). The 3 COVID-19-negative family members (Family Members 1-3) did not have CT abnormalities, and they showed negative reverse transcription-polymerase chain reaction (RT-PCR) results twice.

Conclusions

CT screening is necessary in close-contact family members of a confirmed COVID-19 pneumonia case, regardless of the presence of clinical symptoms.

Authors+Show Affiliations

Zengcheng District People's Hospital of Guangzhou, Guangzhou, China.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China.Brown University, Providence, RI, USA.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.Zengcheng District People's Hospital of Guangzhou, Guangzhou, China. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32802446

Citation

Liu, Zhifeng, et al. "Investigation of a Family Cluster Outbreak of COVID-19 Indicates the Necessity of CT Screening for Asymptomatic Family Members in Close Contact With Confirmed Patients." Journal of Thoracic Disease, vol. 12, no. 7, 2020, pp. 3673-3681.
Liu Z, Wu Q, Zou Z, et al. Investigation of a family cluster outbreak of COVID-19 indicates the necessity of CT screening for asymptomatic family members in close contact with confirmed patients. J Thorac Dis. 2020;12(7):3673-3681.
Liu, Z., Wu, Q., Zou, Z., Yao, Y., Cai, J., Liu, T., Yang, Z., & Liu, Q. (2020). Investigation of a family cluster outbreak of COVID-19 indicates the necessity of CT screening for asymptomatic family members in close contact with confirmed patients. Journal of Thoracic Disease, 12(7), 3673-3681. https://doi.org/10.21037/jtd-20-955
Liu Z, et al. Investigation of a Family Cluster Outbreak of COVID-19 Indicates the Necessity of CT Screening for Asymptomatic Family Members in Close Contact With Confirmed Patients. J Thorac Dis. 2020;12(7):3673-3681. PubMed PMID: 32802446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of a family cluster outbreak of COVID-19 indicates the necessity of CT screening for asymptomatic family members in close contact with confirmed patients. AU - Liu,Zhifeng, AU - Wu,Qiwen, AU - Zou,Zhikang, AU - Yao,Yeping, AU - Cai,Jinhui, AU - Liu,Tao, AU - Yang,Zhengfei, AU - Liu,Qingyu, PY - 2020/8/18/entrez PY - 2020/8/18/pubmed PY - 2020/8/18/medline KW - 2019-novel coronavirus (2019-nCoV) KW - computed tomography KW - coronavirus disease (COVID-19) KW - pneumonia SP - 3673 EP - 3681 JF - Journal of thoracic disease JO - J Thorac Dis VL - 12 IS - 7 N2 - Background: To investigate whether asymptomatic close-contact family members of patients diagnosed with coronavirus disease (COVID-19) should immediately undergo CT screening in addition to the viral nucleic acid test. Methods: We retrospectively analyzed the data of a family cluster of 8 individuals, of whom 1 family member (Patient 3) had an epidemiologic history of having visited Guangzhou from Hubei Province on January 20, 2020. Her father (Patient 1) developed a fever and respiratory system symptoms and was confirmed COVID-19-positive on February 4-5, 2020 at Zengcheng People's Hospital, Guangzhou, China. Seven close-contact family members of the patients were then screened for COVID-19 on February 5-6 at the hospital. The CT imaging manifestation and laboratory tests of this family cluster were investigated and reported. Results: Five (62.5%) of the 8 family members were confirmed COVID-19-positive. Except for Patient 1, who had fever, cough, fatigue, and dizziness, the remaining four (4/5, 80%) COVID-19-positive family members (Patients 2-5) had no clinical symptoms. Among the 5 patients, 2 had leukopenia (2/5, 40%), 1 had low absolute neutrophil counts (1/5, 20%), and 2 had increased high-sensitivity C-reactive protein (2/5, 40%). Ground-glass opacity (GGO) was found on chest CT imaging in all 5 patients (5/5, 100%), with interlobular septal thickening. Thickened blood vessel shadows were seen in 3 patients (3/5, 60%). The 3 COVID-19-negative family members (Family Members 1-3) did not have CT abnormalities, and they showed negative reverse transcription-polymerase chain reaction (RT-PCR) results twice. Conclusions: CT screening is necessary in close-contact family members of a confirmed COVID-19 pneumonia case, regardless of the presence of clinical symptoms. SN - 2072-1439 UR - https://www.unboundmedicine.com/medline/citation/32802446/Investigation_of_a_family_cluster_outbreak_of_COVID_19_indicates_the_necessity_of_CT_screening_for_asymptomatic_family_members_in_close_contact_with_confirmed_patients_ L2 - https://doi.org/10.21037/jtd-20-955 DB - PRIME DP - Unbound Medicine ER -
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