Citation
Pawlowski, Colin, et al. "Inference From Longitudinal Laboratory Tests Characterizes Temporal Evolution of COVID-19-associated Coagulopathy (CAC)." ELife, vol. 9, 2020.
Pawlowski C, Wagner T, Puranik A, et al. Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC). Elife. 2020;9.
Pawlowski, C., Wagner, T., Puranik, A., Murugadoss, K., Loscalzo, L., Venkatakrishnan, A. J., Pruthi, R. K., Houghton, D. E., O'Horo, J. C., Morice, W. G., Williams, A. W., Gores, G. J., Halamka, J., Badley, A. D., Barnathan, E. S., Makimura, H., Khan, N., & Soundararajan, V. (2020). Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC). ELife, 9. https://doi.org/10.7554/eLife.59209
Pawlowski C, et al. Inference From Longitudinal Laboratory Tests Characterizes Temporal Evolution of COVID-19-associated Coagulopathy (CAC). Elife. 2020 08 17;9 PubMed PMID: 32804081.
TY - JOUR
T1 - Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC).
AU - Pawlowski,Colin,
AU - Wagner,Tyler,
AU - Puranik,Arjun,
AU - Murugadoss,Karthik,
AU - Loscalzo,Liam,
AU - Venkatakrishnan,A J,
AU - Pruthi,Rajiv K,
AU - Houghton,Damon E,
AU - O'Horo,John C,
AU - Morice,William G,2nd
AU - Williams,Amy W,
AU - Gores,Gregory J,
AU - Halamka,John,
AU - Badley,Andrew D,
AU - Barnathan,Elliot S,
AU - Makimura,Hideo,
AU - Khan,Najat,
AU - Soundararajan,Venky,
Y1 - 2020/08/17/
PY - 2020/05/22/received
PY - 2020/08/14/accepted
PY - 2020/8/18/pubmed
PY - 2020/9/17/medline
PY - 2020/8/18/entrez
KW - COVID-19
KW - SARS-CoV-2
KW - coagulation
KW - electronic health record (EHR)
KW - human
KW - laboratory tests
KW - medicine
KW - thrombolytic agents
JF - eLife
JO - Elife
VL - 9
N2 - Temporal inference from laboratory testing results and triangulation with clinical outcomes extracted from unstructured electronic health record (EHR) provider notes is integral to advancing precision medicine. Here, we studied 246 SARS-CoV-2 PCR-positive (COVIDpos) patients and propensity-matched 2460 SARS-CoV-2 PCR-negative (COVIDneg) patients subjected to around 700,000 lab tests cumulatively across 194 assays. Compared to COVIDneg patients at the time of diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and lower platelet counts. However, as the infection evolves, COVIDpos patients distinctively show declining fibrinogen, increasing platelet counts, and lower white blood cell counts. Augmented curation of EHRs suggests that only a minority of COVIDpos patients develop thromboembolism, and rarely, disseminated intravascular coagulopathy (DIC), with patients generally not displaying platelet reductions typical of consumptive coagulopathies. These temporal trends provide fine-grained resolution into COVID-19 associated coagulopathy (CAC) and set the stage for personalizing thromboprophylaxis.
SN - 2050-084X
UR - https://www.unboundmedicine.com/medline/citation/32804081/Inference_from_longitudinal_laboratory_tests_characterizes_temporal_evolution_of_COVID_19_associated_coagulopathy__CAC__
DB - PRIME
DP - Unbound Medicine
ER -