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Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients.
Clin Immunol. 2020 10; 219:108572.CI

Abstract

Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk.

Authors+Show Affiliations

Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Microbiology Department. Hospital Universitario Marqués de Valdecilla. Santander. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Infectious Disease Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain.Immunology Department. Hospital Universitario Ramón y Cajal. Madrid. Spain. Electronic address: israel.ganan@salud.madrid.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32810602

Citation

Iturrieta-Zuazo, Ignacio, et al. "Possible Role of HLA class-I Genotype in SARS-CoV-2 Infection and Progression: a Pilot Study in a Cohort of Covid-19 Spanish Patients." Clinical Immunology (Orlando, Fla.), vol. 219, 2020, p. 108572.
Iturrieta-Zuazo I, Rita CG, García-Soidán A, et al. Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients. Clin Immunol. 2020;219:108572.
Iturrieta-Zuazo, I., Rita, C. G., García-Soidán, A., de Malet Pintos-Fonseca, A., Alonso-Alarcón, N., Pariente-Rodríguez, R., Tejeda-Velarde, A., Serrano-Villar, S., Castañer-Alabau, J. L., & Nieto-Gañán, I. (2020). Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients. Clinical Immunology (Orlando, Fla.), 219, 108572. https://doi.org/10.1016/j.clim.2020.108572
Iturrieta-Zuazo I, et al. Possible Role of HLA class-I Genotype in SARS-CoV-2 Infection and Progression: a Pilot Study in a Cohort of Covid-19 Spanish Patients. Clin Immunol. 2020;219:108572. PubMed PMID: 32810602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients. AU - Iturrieta-Zuazo,Ignacio, AU - Rita,Claudia Geraldine, AU - García-Soidán,Ana, AU - de Malet Pintos-Fonseca,Ana, AU - Alonso-Alarcón,Nieves, AU - Pariente-Rodríguez,Roberto, AU - Tejeda-Velarde,Amalia, AU - Serrano-Villar,Sergio, AU - Castañer-Alabau,José Luis, AU - Nieto-Gañán,Israel, Y1 - 2020/08/15/ PY - 2020/06/09/received PY - 2020/08/07/revised PY - 2020/08/12/accepted PY - 2020/8/19/pubmed PY - 2020/9/15/medline PY - 2020/8/19/entrez KW - Evolution disease KW - HLA class I KW - SARS-CoV-2 KW - Viral peptide-MHC class I binding affinity SP - 108572 EP - 108572 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 219 N2 - Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/32810602/Possible_role_of_HLA_class_I_genotype_in_SARS_CoV_2_infection_and_progression:_A_pilot_study_in_a_cohort_of_Covid_19_Spanish_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(20)30732-4 DB - PRIME DP - Unbound Medicine ER -