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The profile of urinary biomarkers in overactive bladder.
Neurourol Urodyn. 2020 11; 39(8):2305-2313.NU

Abstract

AIMS

In overactive bladder (OAB) research, different biomarkers have been proposed as diagnostic tools and may be used to create individual patient profiles. Assessing the diagnostic performance of biomarkers would better outline their utility. Therefore, our aim was to investigate the diagnostic value of four urinary biomarkers: human brain derived neurotrophic factor (hBDNF), malondialdehyde (MDA), h nerve growth factor (hNGF) and h 8-hydroxydeoxyguanosine in women with OAB. These are neurotrophins/oxidative stress markers that have been linked to lower urinary tract symptoms.

METHODS

A total of 105 women were included in the study and distributed in two groups: a group with OAB (n = 53) and a control group (n = 50). The levels of the biomarkers were determined using enzyme-linked immunosorbent assay technique and they were compared between the groups. If the Mann-Whitney test demonstrated a statistically significant difference, receiver operating curves (ROC) analysis was undertaken.

RESULTS

When normalized to urinary creatinine, hBDNF, MDA, and hNGF showed significantly increased values in women with OAB as compared to controls, whereas 8-OHdG showed no significant difference. The diagnostic performance of these biomarkers was analyzed based on the area under the ROC curve (AUC). MDA had the highest AUC (0.75), followed by hNGF (0.69) and hBDNF (0.67).

CONCLUSIONS

Our findings suggest that MDA, a relatively novel biomarker in OAB research, has a fair performance as a diagnostic tool for OAB. Moreover, urinary neurotrophins (NGF and BDNF) as biomarkers may have a role in the diagnostic pathways of women with OAB symptoms.

Authors+Show Affiliations

2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.Department of Obstetrics and Gynaecology, Epsom & St Helier University Hospitals NHS Trust, UK. Institute of Medical and Biomedical Education, St George's University of London, London, UK. Laboratory of Experimental Surgery and Surgical Research N S Christeas, Athens University Medical School, Athens, Greece. American University of the Caribbean School of Medicine, Florida.2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.Department of Radiology, "Prof. Dr. Ion Chiricuţă" Oncology Institute Cluj-Napoca, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.2nd Department of Obstetrics-Gynaecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32813897

Citation

Rada, Maria Patricia, et al. "The Profile of Urinary Biomarkers in Overactive Bladder." Neurourology and Urodynamics, vol. 39, no. 8, 2020, pp. 2305-2313.
Rada MP, Ciortea R, Măluţan AM, et al. The profile of urinary biomarkers in overactive bladder. Neurourol Urodyn. 2020;39(8):2305-2313.
Rada, M. P., Ciortea, R., Măluţan, A. M., Doumouchtsis, S. K., Bucuri, C. E., Clim, A., Roman, A., & Mihu, D. (2020). The profile of urinary biomarkers in overactive bladder. Neurourology and Urodynamics, 39(8), 2305-2313. https://doi.org/10.1002/nau.24487
Rada MP, et al. The Profile of Urinary Biomarkers in Overactive Bladder. Neurourol Urodyn. 2020;39(8):2305-2313. PubMed PMID: 32813897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The profile of urinary biomarkers in overactive bladder. AU - Rada,Maria Patricia, AU - Ciortea,Răzvan, AU - Măluţan,Andrei Mihai, AU - Doumouchtsis,Stergios K, AU - Bucuri,Carmen Elena, AU - Clim,Adelina, AU - Roman,Andrei, AU - Mihu,Dan, Y1 - 2020/08/19/ PY - 2020/05/20/received PY - 2020/08/06/accepted PY - 2020/8/20/pubmed PY - 2021/3/3/medline PY - 2020/8/20/entrez KW - 8-Hydroxydeoxyguanosine KW - brain-derived neurotrophic factor KW - lower urinary tract symptoms KW - malondialdehyde KW - nerve growth factor KW - overactive bladder KW - urinary biomarkers SP - 2305 EP - 2313 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 39 IS - 8 N2 - AIMS: In overactive bladder (OAB) research, different biomarkers have been proposed as diagnostic tools and may be used to create individual patient profiles. Assessing the diagnostic performance of biomarkers would better outline their utility. Therefore, our aim was to investigate the diagnostic value of four urinary biomarkers: human brain derived neurotrophic factor (hBDNF), malondialdehyde (MDA), h nerve growth factor (hNGF) and h 8-hydroxydeoxyguanosine in women with OAB. These are neurotrophins/oxidative stress markers that have been linked to lower urinary tract symptoms. METHODS: A total of 105 women were included in the study and distributed in two groups: a group with OAB (n = 53) and a control group (n = 50). The levels of the biomarkers were determined using enzyme-linked immunosorbent assay technique and they were compared between the groups. If the Mann-Whitney test demonstrated a statistically significant difference, receiver operating curves (ROC) analysis was undertaken. RESULTS: When normalized to urinary creatinine, hBDNF, MDA, and hNGF showed significantly increased values in women with OAB as compared to controls, whereas 8-OHdG showed no significant difference. The diagnostic performance of these biomarkers was analyzed based on the area under the ROC curve (AUC). MDA had the highest AUC (0.75), followed by hNGF (0.69) and hBDNF (0.67). CONCLUSIONS: Our findings suggest that MDA, a relatively novel biomarker in OAB research, has a fair performance as a diagnostic tool for OAB. Moreover, urinary neurotrophins (NGF and BDNF) as biomarkers may have a role in the diagnostic pathways of women with OAB symptoms. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/32813897/The_profile_of_urinary_biomarkers_in_overactive_bladder_ L2 - https://doi.org/10.1002/nau.24487 DB - PRIME DP - Unbound Medicine ER -