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Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction.
NMR Biomed. 2020 Nov; 33(11):e4394.NB

Abstract

Preclinical 4D flow MRI remains challenging and is restricted for parallel imaging acceleration due to the limited number of available receive channels. A radial acquisition with combined parallel imaging and temporal compressed sensing reconstruction was implemented to achieve accelerated preclinical 4D flow MRI. In order to increase the accuracy of the measured velocities, a quantitative evaluation of different temporal regularization weights for the compressed sensing reconstruction based on velocity instead of magnitude data is performed. A 3D radial retrospectively triggered phase contrast sequence with a combined parallel imaging and compressed sensing reconstruction with temporal regularization was developed. It was validated in a phantom and in vivo (C57BL/6 J mice), against an established fully sampled Cartesian sequence. Different undersampling factors (USFs [12, 15, 20, 30, 60]) were evaluated, and the effect of undersampling was analyzed in detail for magnitude and velocity data. Temporal regularization weights λ were evaluated for different USFs. Acceleration factors of up to 20 compared with full Nyquist sampling were achieved. The peak flow differences compared with the Cartesian measurement were the following: USF 12, 3.38%; USF 15, 4.68%; USF 20, 0.95%. The combination of 3D radial center-out trajectories and compressed sensing reconstruction is robust against motion and flow artifacts and can significantly reduce measurement time to 30 min at a resolution of 180 μm3 . Concisely, radial acquisition with combined compressed sensing and parallel imaging proved to be an excellent method for analyzing complex flow patterns in mice.

Authors+Show Affiliations

Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Departments of Radiology and Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York.Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan.Department of Cardiology and Angiology I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.Department of Radiology Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32815236

Citation

Braig, Moritz, et al. "Analysis of Accelerated 4D Flow MRI in the Murine Aorta By Radial Acquisition and Compressed Sensing Reconstruction." NMR in Biomedicine, vol. 33, no. 11, 2020, pp. e4394.
Braig M, Menza M, Leupold J, et al. Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction. NMR Biomed. 2020;33(11):e4394.
Braig, M., Menza, M., Leupold, J., LeVan, P., Feng, L., Ko, C. W., von Zur Mühlen, C., Krafft, A. J., Hennig, J., & von Elverfeldt, D. (2020). Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction. NMR in Biomedicine, 33(11), e4394. https://doi.org/10.1002/nbm.4394
Braig M, et al. Analysis of Accelerated 4D Flow MRI in the Murine Aorta By Radial Acquisition and Compressed Sensing Reconstruction. NMR Biomed. 2020;33(11):e4394. PubMed PMID: 32815236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction. AU - Braig,Moritz, AU - Menza,Marius, AU - Leupold,Jochen, AU - LeVan,Pierre, AU - Feng,Li, AU - Ko,Cheng-Wen, AU - von Zur Mühlen,Constantin, AU - Krafft,Axel J, AU - Hennig,Juergen, AU - von Elverfeldt,Dominik, Y1 - 2020/08/19/ PY - 2019/11/14/received PY - 2020/07/15/revised PY - 2020/07/25/accepted PY - 2020/8/21/pubmed PY - 2020/8/21/medline PY - 2020/8/21/entrez KW - 4D flow KW - aorta KW - cardiovascular MRI KW - compressed sensing KW - phase contrast KW - preclinical MRI SP - e4394 EP - e4394 JF - NMR in biomedicine JO - NMR Biomed VL - 33 IS - 11 N2 - Preclinical 4D flow MRI remains challenging and is restricted for parallel imaging acceleration due to the limited number of available receive channels. A radial acquisition with combined parallel imaging and temporal compressed sensing reconstruction was implemented to achieve accelerated preclinical 4D flow MRI. In order to increase the accuracy of the measured velocities, a quantitative evaluation of different temporal regularization weights for the compressed sensing reconstruction based on velocity instead of magnitude data is performed. A 3D radial retrospectively triggered phase contrast sequence with a combined parallel imaging and compressed sensing reconstruction with temporal regularization was developed. It was validated in a phantom and in vivo (C57BL/6 J mice), against an established fully sampled Cartesian sequence. Different undersampling factors (USFs [12, 15, 20, 30, 60]) were evaluated, and the effect of undersampling was analyzed in detail for magnitude and velocity data. Temporal regularization weights λ were evaluated for different USFs. Acceleration factors of up to 20 compared with full Nyquist sampling were achieved. The peak flow differences compared with the Cartesian measurement were the following: USF 12, 3.38%; USF 15, 4.68%; USF 20, 0.95%. The combination of 3D radial center-out trajectories and compressed sensing reconstruction is robust against motion and flow artifacts and can significantly reduce measurement time to 30 min at a resolution of 180 μm3 . Concisely, radial acquisition with combined compressed sensing and parallel imaging proved to be an excellent method for analyzing complex flow patterns in mice. SN - 1099-1492 UR - https://www.unboundmedicine.com/medline/citation/32815236/Analysis_of_accelerated_4D_flow_MRI_in_the_murine_aorta_by_radial_acquisition_and_compressed_sensing_reconstruction_ L2 - https://doi.org/10.1002/nbm.4394 DB - PRIME DP - Unbound Medicine ER -
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