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Surveillance of SARS-CoV-2 infection among frontline health care workers in Wuhan during COVID-19 outbreak.
Immun Inflamm Dis. 2020 12; 8(4):840-843.II

Abstract

INTRODUCTION

As an emerging infectious disease, coronavirus disease 2019 (COVID-19) has rapidly spread throughout worldwide. Health care workers (HCWs) on frontline directly participated in the diagnosis, treatment, and care of COVID-19 patients are at high risk of getting infected with the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes COVID-19. In Nanjing Drum Tower Hospital, a total of 222 medical staff went to Wuhan city for support. In this study, we aimed to determine any nosocomial infection among our cohort of HCWs who worked in Wuhan.

METHODS

Throat swab samples were obtained for RNA testing on day 1 and 14 of their quarantine upon their return to Nanjing. Radiological assessments were performed by chest computed tomography (CT) on day 14 of their quarantine. The blood was collected from 191 HCWs between May 12 and May 15. Anti-SARS-CoV-2 immunoglobulin M (IgM) and IgG antibody responses were determined by a chemiluminescence immunoassay.

RESULTS

All the throat swab specimens were found negative for SARS-CoV-2. The radiological analysis revealed that there was no typical chest CT scan of COVID-19 among 222 HCWs. Consistently, anti-SARS-CoV-2 IgM or IgG was also found to be negative among 191 HCWs.

CONCLUSIONS

There was no nosocomial infection of SARS-CoV-2 among our cohort of the frontline HCWs, suggesting that zero occupational infection is an achievable goal with appropriate training, strict compliance, and psychological support for the frontline HCWs.

Authors+Show Affiliations

Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32816387

Citation

Tong, Xin, et al. "Surveillance of SARS-CoV-2 Infection Among Frontline Health Care Workers in Wuhan During COVID-19 Outbreak." Immunity, Inflammation and Disease, vol. 8, no. 4, 2020, pp. 840-843.
Tong X, Ning M, Huang R, et al. Surveillance of SARS-CoV-2 infection among frontline health care workers in Wuhan during COVID-19 outbreak. Immun Inflamm Dis. 2020;8(4):840-843.
Tong, X., Ning, M., Huang, R., Jia, B., Yan, X., Xiong, Y., Wu, W., Liu, J., Chen, Y., & Wu, C. (2020). Surveillance of SARS-CoV-2 infection among frontline health care workers in Wuhan during COVID-19 outbreak. Immunity, Inflammation and Disease, 8(4), 840-843. https://doi.org/10.1002/iid3.340
Tong X, et al. Surveillance of SARS-CoV-2 Infection Among Frontline Health Care Workers in Wuhan During COVID-19 Outbreak. Immun Inflamm Dis. 2020;8(4):840-843. PubMed PMID: 32816387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surveillance of SARS-CoV-2 infection among frontline health care workers in Wuhan during COVID-19 outbreak. AU - Tong,Xin, AU - Ning,Mingzhe, AU - Huang,Rui, AU - Jia,Bei, AU - Yan,Xiaomin, AU - Xiong,Yali, AU - Wu,Weihua, AU - Liu,Jiacheng, AU - Chen,Yuxin, AU - Wu,Chao, Y1 - 2020/08/20/ PY - 2020/08/07/received PY - 2020/08/10/accepted PY - 2020/8/21/pubmed PY - 2020/11/25/medline PY - 2020/8/21/entrez SP - 840 EP - 843 JF - Immunity, inflammation and disease JO - Immun Inflamm Dis VL - 8 IS - 4 N2 - INTRODUCTION: As an emerging infectious disease, coronavirus disease 2019 (COVID-19) has rapidly spread throughout worldwide. Health care workers (HCWs) on frontline directly participated in the diagnosis, treatment, and care of COVID-19 patients are at high risk of getting infected with the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes COVID-19. In Nanjing Drum Tower Hospital, a total of 222 medical staff went to Wuhan city for support. In this study, we aimed to determine any nosocomial infection among our cohort of HCWs who worked in Wuhan. METHODS: Throat swab samples were obtained for RNA testing on day 1 and 14 of their quarantine upon their return to Nanjing. Radiological assessments were performed by chest computed tomography (CT) on day 14 of their quarantine. The blood was collected from 191 HCWs between May 12 and May 15. Anti-SARS-CoV-2 immunoglobulin M (IgM) and IgG antibody responses were determined by a chemiluminescence immunoassay. RESULTS: All the throat swab specimens were found negative for SARS-CoV-2. The radiological analysis revealed that there was no typical chest CT scan of COVID-19 among 222 HCWs. Consistently, anti-SARS-CoV-2 IgM or IgG was also found to be negative among 191 HCWs. CONCLUSIONS: There was no nosocomial infection of SARS-CoV-2 among our cohort of the frontline HCWs, suggesting that zero occupational infection is an achievable goal with appropriate training, strict compliance, and psychological support for the frontline HCWs. SN - 2050-4527 UR - https://www.unboundmedicine.com/medline/citation/32816387/Surveillance_of_SARS_CoV_2_infection_among_frontline_health_care_workers_in_Wuhan_during_COVID_19_outbreak_ L2 - https://doi.org/10.1002/iid3.340 DB - PRIME DP - Unbound Medicine ER -