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The indoleamine hypothesis of depression: an overview and pilot study.
Dis Nerv Syst. 1977 Aug; 38(8):646-53.DN

Abstract

This paper reviews the evidence for a specific indoleamine deficiency in depression and the attempts to correct this suspected deficiency with serotonin precursors. It also presents the clinical and biochemical data on six patients with depression treated with L-5-HTP in a nonrandom, double-blind protocol. The oral administration of L5-HTP was associated with a rise in CSF5-HIAA, but only two of six patients studied had any decrease in depression ratings. 5-HTP was also shown to decrease urinary excretion of 17 hydroxycorticosteroids in twodepressed patients and three normal controls suggesting an interrelationship between serotonin metabolism and the pituitary adrenal system. This leads to the suggestion that in a postulated subgroup of depressed patients with pituitary adrenal hyperactivity and evidence of serotonin deficiency, L5-HTP deserves a further trial as an experimental treatment.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

328245

Citation

Zarcone, V P., et al. "The Indoleamine Hypothesis of Depression: an Overview and Pilot Study." Diseases of the Nervous System, vol. 38, no. 8, 1977, pp. 646-53.
Zarcone VP, Berger PA, Brodie KH, et al. The indoleamine hypothesis of depression: an overview and pilot study. Dis Nerv Syst. 1977;38(8):646-53.
Zarcone, V. P., Berger, P. A., Brodie, K. H., Sack, R., & Barchas, J. D. (1977). The indoleamine hypothesis of depression: an overview and pilot study. Diseases of the Nervous System, 38(8), 646-53.
Zarcone VP, et al. The Indoleamine Hypothesis of Depression: an Overview and Pilot Study. Dis Nerv Syst. 1977;38(8):646-53. PubMed PMID: 328245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The indoleamine hypothesis of depression: an overview and pilot study. AU - Zarcone,V P,Jr AU - Berger,P A, AU - Brodie,K H, AU - Sack,R, AU - Barchas,J D, PY - 1977/8/1/pubmed PY - 2001/3/28/medline PY - 1977/8/1/entrez SP - 646 EP - 53 JF - Diseases of the nervous system JO - Dis Nerv Syst VL - 38 IS - 8 N2 - This paper reviews the evidence for a specific indoleamine deficiency in depression and the attempts to correct this suspected deficiency with serotonin precursors. It also presents the clinical and biochemical data on six patients with depression treated with L-5-HTP in a nonrandom, double-blind protocol. The oral administration of L5-HTP was associated with a rise in CSF5-HIAA, but only two of six patients studied had any decrease in depression ratings. 5-HTP was also shown to decrease urinary excretion of 17 hydroxycorticosteroids in twodepressed patients and three normal controls suggesting an interrelationship between serotonin metabolism and the pituitary adrenal system. This leads to the suggestion that in a postulated subgroup of depressed patients with pituitary adrenal hyperactivity and evidence of serotonin deficiency, L5-HTP deserves a further trial as an experimental treatment. SN - 0012-3714 UR - https://www.unboundmedicine.com/medline/citation/328245/The_indoleamine_hypothesis_of_depression:_an_overview_and_pilot_study_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -