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Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?
Nutrients. 2020 Aug 18; 12(8)N

Abstract

The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50-75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2) overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and 1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, 41% (95% confidence interval: 20-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D3 supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, Germany Cancer Research Center (DKFZ), 69118 Heidelberg, Germany. Division of Preventive Oncology, Germany Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany. German Cancer Consortium (DKTK), Germany Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Network Aging Research, University of Heidelberg, 69115 Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, Germany Cancer Research Center (DKFZ), 69118 Heidelberg, Germany. Saarland Cancer Registry, 66119 Saarbrücken, Germany.Division of Clinical Epidemiology and Aging Research, Germany Cancer Research Center (DKFZ), 69118 Heidelberg, Germany. Network Aging Research, University of Heidelberg, 69115 Heidelberg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32824839

Citation

Brenner, Hermann, et al. "Vitamin D Insufficiency and Deficiency and Mortality From Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll During and Beyond the COVID-19 Pandemic?" Nutrients, vol. 12, no. 8, 2020.
Brenner H, Holleczek B, Schöttker B. Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic? Nutrients. 2020;12(8).
Brenner, H., Holleczek, B., & Schöttker, B. (2020). Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic? Nutrients, 12(8). https://doi.org/10.3390/nu12082488
Brenner H, Holleczek B, Schöttker B. Vitamin D Insufficiency and Deficiency and Mortality From Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll During and Beyond the COVID-19 Pandemic. Nutrients. 2020 Aug 18;12(8) PubMed PMID: 32824839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic? AU - Brenner,Hermann, AU - Holleczek,Bernd, AU - Schöttker,Ben, Y1 - 2020/08/18/ PY - 2020/07/22/received PY - 2020/08/11/revised PY - 2020/08/14/accepted PY - 2020/8/23/entrez PY - 2020/8/23/pubmed PY - 2020/9/9/medline KW - COVID-19 KW - mortality KW - respiratory disease KW - vitamin D JF - Nutrients JO - Nutrients VL - 12 IS - 8 N2 - The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50-75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2) overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and 1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, 41% (95% confidence interval: 20-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D3 supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32824839/Vitamin_D_Insufficiency_and_Deficiency_and_Mortality_from_Respiratory_Diseases_in_a_Cohort_of_Older_Adults:_Potential_for_Limiting_the_Death_Toll_during_and_beyond_the_COVID_19_Pandemic DB - PRIME DP - Unbound Medicine ER -