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MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases.
Int J Mol Sci. 2020 Aug 20; 21(17)IJ

Abstract

Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying these disorders are essential to develop therapeutic approaches. MicroRNAs (miRNAs) are short non-coding RNAs implicated in gene expression regulation at the post-transcriptional level. Moreover, miRNAs are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. Altered miRNAs levels have been associated with the formation of reactive oxygen species (ROS) and mitochondrial dysfunction. Mitochondrial dysfunction and ROS formation occur in many neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. The crosstalk existing among oxidative stress, mitochondrial dysfunction and miRNAs dysregulation plays a pivotal role in the onset and progression of neurodegenerative diseases. Based on this evidence, in this review, with a focus on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets.

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Authors+Show Affiliations

Catanesi M
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
d'Angelo M
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Tupone MG
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy. Center for Microscopy, University of L'Aquila, 67100 L'Aquila, Italy.
Benedetti E
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Giordano A
Sbarro Institute for Cancer Research and Molecular Medicine and Centre for Biotechnology, Temple University, Philadelphia, PA 19122, USA. Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Castelli V
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Cimini A
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy. Sbarro Institute for Cancer Research and Molecular Medicine and Centre for Biotechnology, Temple University, Philadelphia, PA 19122, USA.

MeSH

AgingApoptosisGene Expression RegulationHumansMicroRNAsMitochondriaNeurodegenerative DiseasesReactive Oxygen Species

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32825273

Citation

Catanesi, Mariano, et al. "MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 21, no. 17, 2020.
Catanesi M, d'Angelo M, Tupone MG, et al. MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases. Int J Mol Sci. 2020;21(17).
Catanesi, M., d'Angelo, M., Tupone, M. G., Benedetti, E., Giordano, A., Castelli, V., & Cimini, A. (2020). MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases. International Journal of Molecular Sciences, 21(17). https://doi.org/10.3390/ijms21175986
Catanesi M, et al. MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases. Int J Mol Sci. 2020 Aug 20;21(17) PubMed PMID: 32825273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases. AU - Catanesi,Mariano, AU - d'Angelo,Michele, AU - Tupone,Maria Grazia, AU - Benedetti,Elisabetta, AU - Giordano,Antonio, AU - Castelli,Vanessa, AU - Cimini,Annamaria, Y1 - 2020/08/20/ PY - 2020/07/20/received PY - 2020/08/12/revised PY - 2020/08/18/accepted PY - 2020/8/23/entrez PY - 2020/8/23/pubmed PY - 2021/4/14/medline KW - aging KW - miRNAs KW - mitochondrial dysfunction KW - neurodegenerative disease KW - reactive oxygen species JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 17 N2 - Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying these disorders are essential to develop therapeutic approaches. MicroRNAs (miRNAs) are short non-coding RNAs implicated in gene expression regulation at the post-transcriptional level. Moreover, miRNAs are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. Altered miRNAs levels have been associated with the formation of reactive oxygen species (ROS) and mitochondrial dysfunction. Mitochondrial dysfunction and ROS formation occur in many neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. The crosstalk existing among oxidative stress, mitochondrial dysfunction and miRNAs dysregulation plays a pivotal role in the onset and progression of neurodegenerative diseases. Based on this evidence, in this review, with a focus on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32825273/MicroRNAs_Dysregulation_and_Mitochondrial_Dysfunction_in_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -