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Pathologic features of COVID-19: A concise review.
Pathol Res Pract. 2020 Sep; 216(9):153097.PR

Abstract

The novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), first appeared in December 2019, in Wuhan, China and evolved into a pandemic. As Angiotensin-Converting Enzyme 2 (ACE2) is one of the potential target receptors for SARS-CoV-2 in human body, which is expressed in different tissues, multiple organs might become affected. In the initial phase of the current pandemic, a handful of post-mortem case-series revealed COVID-19-related pathological changes in various organs. Although pathological examination is not a feasible method of diagnosis, it can elucidate pathological changes, pathogenesis of the disease, and the cause of death in COVID-19 cases. Herein, we thoroughly reviewed multiple organs including lung, gastrointestinal tract, liver, kidney, skin, heart, blood, spleen, lymph nodes, brain, blood vessels, and placenta in terms of COVID-19-related pathological alterations. Also, these findings were compared with SARS and MERS infection, wherever applicable. We found a diverse range of pathological changes, some of which resemble those found in SARS and MERS.

Authors+Show Affiliations

Experimental Medicine Research Center, Tehran University of Medical Center, Tehran, Iran.School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: tavangar@ams.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32825963

Citation

Tabary, Mohammadreza, et al. "Pathologic Features of COVID-19: a Concise Review." Pathology, Research and Practice, vol. 216, no. 9, 2020, p. 153097.
Tabary M, Khanmohammadi S, Araghi F, et al. Pathologic features of COVID-19: A concise review. Pathol Res Pract. 2020;216(9):153097.
Tabary, M., Khanmohammadi, S., Araghi, F., Dadkhahfar, S., & Tavangar, S. M. (2020). Pathologic features of COVID-19: A concise review. Pathology, Research and Practice, 216(9), 153097. https://doi.org/10.1016/j.prp.2020.153097
Tabary M, et al. Pathologic Features of COVID-19: a Concise Review. Pathol Res Pract. 2020;216(9):153097. PubMed PMID: 32825963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathologic features of COVID-19: A concise review. AU - Tabary,Mohammadreza, AU - Khanmohammadi,Shaghayegh, AU - Araghi,Farnaz, AU - Dadkhahfar,Sahar, AU - Tavangar,Seyed Mohammad, Y1 - 2020/07/04/ PY - 2020/05/30/received PY - 2020/06/28/revised PY - 2020/07/02/accepted PY - 2020/8/23/entrez PY - 2020/8/23/pubmed PY - 2020/9/4/medline KW - COVID-19 KW - Histopathology KW - Pathology KW - SARS-CoV-2 SP - 153097 EP - 153097 JF - Pathology, research and practice JO - Pathol Res Pract VL - 216 IS - 9 N2 - The novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), first appeared in December 2019, in Wuhan, China and evolved into a pandemic. As Angiotensin-Converting Enzyme 2 (ACE2) is one of the potential target receptors for SARS-CoV-2 in human body, which is expressed in different tissues, multiple organs might become affected. In the initial phase of the current pandemic, a handful of post-mortem case-series revealed COVID-19-related pathological changes in various organs. Although pathological examination is not a feasible method of diagnosis, it can elucidate pathological changes, pathogenesis of the disease, and the cause of death in COVID-19 cases. Herein, we thoroughly reviewed multiple organs including lung, gastrointestinal tract, liver, kidney, skin, heart, blood, spleen, lymph nodes, brain, blood vessels, and placenta in terms of COVID-19-related pathological alterations. Also, these findings were compared with SARS and MERS infection, wherever applicable. We found a diverse range of pathological changes, some of which resemble those found in SARS and MERS. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/32825963/Pathologic_features_of_COVID_19:_A_concise_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(20)31952-X DB - PRIME DP - Unbound Medicine ER -