Citation
Feng, Liqiang, et al. "An Adenovirus-vectored COVID-19 Vaccine Confers Protection From SARS-COV-2 Challenge in Rhesus Macaques." Nature Communications, vol. 11, no. 1, 2020, p. 4207.
Feng L, Wang Q, Shan C, et al. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nat Commun. 2020;11(1):4207.
Feng, L., Wang, Q., Shan, C., Yang, C., Feng, Y., Wu, J., Liu, X., Zhou, Y., Jiang, R., Hu, P., Liu, X., Zhang, F., Li, P., Niu, X., Liu, Y., Zheng, X., Luo, J., Sun, J., Gu, Y., ... Chen, L. (2020). An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nature Communications, 11(1), 4207. https://doi.org/10.1038/s41467-020-18077-5
Feng L, et al. An Adenovirus-vectored COVID-19 Vaccine Confers Protection From SARS-COV-2 Challenge in Rhesus Macaques. Nat Commun. 2020 08 21;11(1):4207. PubMed PMID: 32826924.
TY - JOUR
T1 - An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques.
AU - Feng,Liqiang,
AU - Wang,Qian,
AU - Shan,Chao,
AU - Yang,Chenchen,
AU - Feng,Ying,
AU - Wu,Jia,
AU - Liu,Xiaolin,
AU - Zhou,Yiwu,
AU - Jiang,Rendi,
AU - Hu,Peiyu,
AU - Liu,Xinglong,
AU - Zhang,Fan,
AU - Li,Pingchao,
AU - Niu,Xuefeng,
AU - Liu,Yichu,
AU - Zheng,Xuehua,
AU - Luo,Jia,
AU - Sun,Jing,
AU - Gu,Yingying,
AU - Liu,Bo,
AU - Xu,Yongcun,
AU - Li,Chufang,
AU - Pan,Weiqi,
AU - Zhao,Jincun,
AU - Ke,Changwen,
AU - Chen,Xinwen,
AU - Xu,Tao,
AU - Zhong,Nanshan,
AU - Guan,Suhua,
AU - Yuan,Zhiming,
AU - Chen,Ling,
Y1 - 2020/08/21/
PY - 2020/04/23/received
PY - 2020/07/30/accepted
PY - 2020/8/23/entrez
PY - 2020/8/23/pubmed
PY - 2020/9/15/medline
SP - 4207
EP - 4207
JF - Nature communications
JO - Nat Commun
VL - 11
IS - 1
N2 - The rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no prophylactic vaccine is available. Here, we report the generation of a replication-incompetent recombinant serotype 5 adenovirus, Ad5-S-nb2, carrying a codon-optimized gene encoding Spike protein (S). In mice and rhesus macaques, intramuscular injection with Ad5-S-nb2 elicits systemic S-specific antibody and cell-mediated immune (CMI) responses. Intranasal inoculation elicits both systemic and pulmonary antibody responses but weaker CMI response. At 30 days after a single vaccination with Ad5-S-nb2 either intramuscularly or intranasally, macaques are protected against SARS-CoV-2 challenge. A subsequent challenge reveals that macaques vaccinated with a 10-fold lower vaccine dosage (1 × 1010 viral particles) are also protected, demonstrating the effectiveness of Ad5-S-nb2 and the possibility of offering more vaccine dosages within a shorter timeframe. Thus, Ad5-S-nb2 is a promising candidate vaccine and warrants further clinical evaluation.
SN - 2041-1723
UR - https://www.unboundmedicine.com/medline/citation/32826924/An_adenovirus_vectored_COVID_19_vaccine_confers_protection_from_SARS_COV_2_challenge_in_rhesus_macaques_
DB - PRIME
DP - Unbound Medicine
ER -