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Bone mineral metabolism in human type 1 (insulin dependent) diabetes mellitus.
Dan Med Bull 1988; 35(2):109-21DM

Abstract

Decreased bone mineral content has been observed in several studies of type 1 (insulin-dependent) diabetics in comparison with age and sex matched control subjects. In type 2 diabetics contradictory results have been obtained, probably related to varying degrees of body overweight in the patients investigated. The decrease in bone mineral content in type 1 diabetics was most pronounced in patients with childhood or adolescent onset of the disease, with ceased beta-cell function, with high insulin dosage, and poor glucose regulation. In a subgroup of patients having all these "risk factors" bone mineral content was decreased some 20%, as compared with patients without any "risk factors", and/or with sex and age matched controls. Bone mineral homeostasis was characterized by increased urinary excretions of bone minerals (calcium, phosphate and magnesium) related to the degree of hyperglycaemia and insulin dosage, by decreased serum concentrations of ionized calcium and magnesium, by increased to normal serum concentrations of phosphate, by a low-normal serum concentration of parathyroid hormone, and by a low-normal serum concentration of 1,25-dihydroxyvitamin D. This indicates a state of functional hypoparathyroidism in type 1 diabetics. Several mechanisms may thus contribute to diabetic osteopenia: Proneness to metabolic acidosis, hypocalcaemia, insulin deficiency and perhaps also hypomagnesaemia and hypoparathyroidism.

Authors+Show Affiliations

Department of Clinical Chemistry, Glostrup Hospital, Copenhagen.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3282809

Citation

McNair, P. "Bone Mineral Metabolism in Human Type 1 (insulin Dependent) Diabetes Mellitus." Danish Medical Bulletin, vol. 35, no. 2, 1988, pp. 109-21.
McNair P. Bone mineral metabolism in human type 1 (insulin dependent) diabetes mellitus. Dan Med Bull. 1988;35(2):109-21.
McNair, P. (1988). Bone mineral metabolism in human type 1 (insulin dependent) diabetes mellitus. Danish Medical Bulletin, 35(2), pp. 109-21.
McNair P. Bone Mineral Metabolism in Human Type 1 (insulin Dependent) Diabetes Mellitus. Dan Med Bull. 1988;35(2):109-21. PubMed PMID: 3282809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral metabolism in human type 1 (insulin dependent) diabetes mellitus. A1 - McNair,P, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 109 EP - 21 JF - Danish medical bulletin JO - Dan Med Bull VL - 35 IS - 2 N2 - Decreased bone mineral content has been observed in several studies of type 1 (insulin-dependent) diabetics in comparison with age and sex matched control subjects. In type 2 diabetics contradictory results have been obtained, probably related to varying degrees of body overweight in the patients investigated. The decrease in bone mineral content in type 1 diabetics was most pronounced in patients with childhood or adolescent onset of the disease, with ceased beta-cell function, with high insulin dosage, and poor glucose regulation. In a subgroup of patients having all these "risk factors" bone mineral content was decreased some 20%, as compared with patients without any "risk factors", and/or with sex and age matched controls. Bone mineral homeostasis was characterized by increased urinary excretions of bone minerals (calcium, phosphate and magnesium) related to the degree of hyperglycaemia and insulin dosage, by decreased serum concentrations of ionized calcium and magnesium, by increased to normal serum concentrations of phosphate, by a low-normal serum concentration of parathyroid hormone, and by a low-normal serum concentration of 1,25-dihydroxyvitamin D. This indicates a state of functional hypoparathyroidism in type 1 diabetics. Several mechanisms may thus contribute to diabetic osteopenia: Proneness to metabolic acidosis, hypocalcaemia, insulin deficiency and perhaps also hypomagnesaemia and hypoparathyroidism. SN - 0907-8916 UR - https://www.unboundmedicine.com/medline/citation/3282809/Bone_mineral_metabolism_in_human_type_1__insulin_dependent__diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -