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Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019.
Cell Transplant. 2020 Jan-Dec; 29:963689720952089.CT

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, originating from Wuhan, China, is known to cause severe acute respiratory symptoms. The occurrence of a cytokine storm in the lungs is a critical step in the disease pathogenesis, as it causes pathological lesions, pulmonary edema, and acute respiratory distress syndrome, potentially resulting in death. Currently, there is no effective treatment that targets the cytokine storm and helps regenerate the damaged tissue. Mesenchymal stem cells (MSCs) are known to act as anti-inflammatory/immunomodulatory candidates and activate endogenous regeneration. As a result, MSC therapy is a potential treatment approach for COVID-19. Intravenous injection of clinical-grade MSCs into COVID-19 patients can induce an immunomodulatory response along with improved lung function. Dental pulp stem cells (DPSCs) are considered a potential source of MSCs for immunomodulation, tissue regeneration, and clinical application. Although some current clinical trials have treated COVID-19 patients with DPSCs, this therapy has not been approved. Here, we review the potential use of DPSCs and their significance in the development of a therapy for COVID-19.

Authors+Show Affiliations

Department of Stem Cell Biology and Regenerative Medicine, 221156National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan. Department of Surgery, College of Veterinary Medicine, South Valley University, Qena, Egypt.Department of Stem Cell Biology and Regenerative Medicine, 221156National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32830527

Citation

Zayed, Mohammed, and Koichiro Iohara. "Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: a Potential Therapy to Treat Coronavirus Disease 2019." Cell Transplantation, vol. 29, 2020, p. 963689720952089.
Zayed M, Iohara K. Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019. Cell Transplant. 2020;29:963689720952089.
Zayed, M., & Iohara, K. (2020). Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019. Cell Transplantation, 29, 963689720952089. https://doi.org/10.1177/0963689720952089
Zayed M, Iohara K. Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: a Potential Therapy to Treat Coronavirus Disease 2019. Cell Transplant. 2020 Jan-Dec;29:963689720952089. PubMed PMID: 32830527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019. AU - Zayed,Mohammed, AU - Iohara,Koichiro, PY - 2020/8/25/entrez PY - 2020/8/25/pubmed PY - 2020/9/1/medline KW - COVID-19 KW - coronavirus KW - cytokines storm KW - dental pulp stem cells KW - immunomodulation KW - regeneration SP - 963689720952089 EP - 963689720952089 JF - Cell transplantation JO - Cell Transplant VL - 29 N2 - The coronavirus disease 2019 (COVID-19) pandemic, originating from Wuhan, China, is known to cause severe acute respiratory symptoms. The occurrence of a cytokine storm in the lungs is a critical step in the disease pathogenesis, as it causes pathological lesions, pulmonary edema, and acute respiratory distress syndrome, potentially resulting in death. Currently, there is no effective treatment that targets the cytokine storm and helps regenerate the damaged tissue. Mesenchymal stem cells (MSCs) are known to act as anti-inflammatory/immunomodulatory candidates and activate endogenous regeneration. As a result, MSC therapy is a potential treatment approach for COVID-19. Intravenous injection of clinical-grade MSCs into COVID-19 patients can induce an immunomodulatory response along with improved lung function. Dental pulp stem cells (DPSCs) are considered a potential source of MSCs for immunomodulation, tissue regeneration, and clinical application. Although some current clinical trials have treated COVID-19 patients with DPSCs, this therapy has not been approved. Here, we review the potential use of DPSCs and their significance in the development of a therapy for COVID-19. SN - 1555-3892 UR - https://www.unboundmedicine.com/medline/citation/32830527/Immunomodulation_and_Regeneration_Properties_of_Dental_Pulp_Stem_Cells:_A_Potential_Therapy_to_Treat_Coronavirus_Disease_2019_ DB - PRIME DP - Unbound Medicine ER -