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Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2.
Cell Physiol Biochem. 2020 Aug 25; 54(4):767-790.CP

Abstract

The pandemic of the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 at the end of 2019 marked the third outbreak of a highly pathogenic coronavirus affecting the human population in the past twenty years. Cross-species zoonotic transmission of SARS-CoV-2 has caused severe pathogenicity and led to more than 655,000 fatalities worldwide until July 28, 2020. Outbursts of this virus underlined the importance of controlling infectious pathogens across international frontiers. Unfortunately, there is currently no clinically approved antiviral drug or vaccine against SARS-CoV-2, although several broad-spectrum antiviral drugs targeting multiple RNA viruses have shown a positive response and improved recovery in patients. In this review, we compile our current knowledge of the emergence, transmission, and pathogenesis of SARS-CoV-2 and explore several features of SARS-CoV-2. We emphasize the current therapeutic approaches used to treat infected patients. We also highlight the results of in vitro and in vivo data from several studies, which have broadened our knowledge of potential drug candidates for the successful treatment of patients infected with and discuss possible virus and host-based treatment options against SARS-CoV-2.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Patil AM
Department of Hematology, West German Cancer Center (WTZ), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Göthert JR
Department of Hematology, West German Cancer Center (WTZ), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Khairnar V
Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, khairnarvs111@gmail.com.

MeSH

AnimalsAntiviral AgentsBetacoronavirusCOVID-19COVID-19 VaccinesCoronaviridaeCoronaviridae InfectionsCoronavirus InfectionsCytokine Release SyndromeCytokinesDrug Delivery SystemsEndocytosisForecastingGenome, ViralGlobal HealthHumansImmunity, HerdImmunization, PassivePandemicsPeptide HydrolasesPneumonia, ViralRNA, ViralReceptors, CoronavirusReceptors, VirusSARS-CoV-2Spike Glycoprotein, CoronavirusViral VaccinesVirus InternalizationVirus ReplicationZoonosesCOVID-19 Drug TreatmentCOVID-19 Serotherapy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32830930

Citation

Patil, Ashwini M., et al. "Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated With the SARS-CoV-2." Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, vol. 54, no. 4, 2020, pp. 767-790.
Patil AM, Göthert JR, Khairnar V. Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2. Cell Physiol Biochem. 2020;54(4):767-790.
Patil, A. M., Göthert, J. R., & Khairnar, V. (2020). Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 54(4), 767-790. https://doi.org/10.33594/000000254
Patil AM, Göthert JR, Khairnar V. Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated With the SARS-CoV-2. Cell Physiol Biochem. 2020 Aug 25;54(4):767-790. PubMed PMID: 32830930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2. AU - Patil,Ashwini M, AU - Göthert,Joachim R, AU - Khairnar,Vishal, PY - 2020/8/14/accepted PY - 2020/8/25/entrez PY - 2020/8/25/pubmed PY - 2020/8/29/medline KW - COVID-19; SARS-CoV-2; Transmission; Therapeutic options; Antiviral therapies SP - 767 EP - 790 JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology JO - Cell Physiol Biochem VL - 54 IS - 4 N2 - The pandemic of the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 at the end of 2019 marked the third outbreak of a highly pathogenic coronavirus affecting the human population in the past twenty years. Cross-species zoonotic transmission of SARS-CoV-2 has caused severe pathogenicity and led to more than 655,000 fatalities worldwide until July 28, 2020. Outbursts of this virus underlined the importance of controlling infectious pathogens across international frontiers. Unfortunately, there is currently no clinically approved antiviral drug or vaccine against SARS-CoV-2, although several broad-spectrum antiviral drugs targeting multiple RNA viruses have shown a positive response and improved recovery in patients. In this review, we compile our current knowledge of the emergence, transmission, and pathogenesis of SARS-CoV-2 and explore several features of SARS-CoV-2. We emphasize the current therapeutic approaches used to treat infected patients. We also highlight the results of in vitro and in vivo data from several studies, which have broadened our knowledge of potential drug candidates for the successful treatment of patients infected with and discuss possible virus and host-based treatment options against SARS-CoV-2. SN - 1421-9778 UR - https://www.unboundmedicine.com/medline/citation/32830930/Emergence_Transmission_and_Potential_Therapeutic_Targets_for_the_COVID_19_Pandemic_Associated_with_the_SARS_CoV_2_ DB - PRIME DP - Unbound Medicine ER -