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Clinical course and characteristics of patients with coronavirus disease 2019 in Wuhan, China: a single-centered, retrospective, observational study.
Aging (Albany NY). 2020 08 24; 12(16):15946-15953.A

Abstract

BACKGROUND

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the virus responsible for the coronavirus disease 2019(COVID-19) pandemic. Despite the extensive studies aiming to understand the pathology of COVID-19, the clinicopathological characteristics and risk factors associated with COVID-19 remain mostly unclear. In this study, we assessed the clinical course and features of COVID-19 patients.

FINDINGS

There were 59 patients (54.1%) that had no fever. One-hundred(91.7%) patients required oxygen therapy, which improved percutaneous oxygen saturation (SpO2). Seventy-two (66.1%) patients aged over 60; these patients were more likely to develop respiratory symptoms. Only 13(11.9%) patients were positive for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleic acid, and computed tomography (CT) findings. We found significant differences in age, respiratory symptoms, and heart rates between patients with and without underlying conditions.

CONCLUSIONS

Our findings suggest that oxygen plays an important role in the treatment of COVID-19 patients and that age and underlying diseases are significant risk factors for COVID-19. Most COVID-19 patients have no fever, and CT provides higher detection rates than antibody- and nucleic acid-based detection methods.

METHODS

We analyzed data from 109 confirmed COVID-19 cases. We compared the clinicopathological characteristic of patients stratified according to age and underlying diseases, as well as assessed the detection rates of different diagnostic methods.

Authors+Show Affiliations

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32833671

Citation

Liu, Yanfang, et al. "Clinical Course and Characteristics of Patients With Coronavirus Disease 2019 in Wuhan, China: a Single-centered, Retrospective, Observational Study." Aging, vol. 12, no. 16, 2020, pp. 15946-15953.
Liu Y, Liu L, Wang Y, et al. Clinical course and characteristics of patients with coronavirus disease 2019 in Wuhan, China: a single-centered, retrospective, observational study. Aging (Albany NY). 2020;12(16):15946-15953.
Liu, Y., Liu, L., Wang, Y., Du, X., Ma, H., & Yao, J. (2020). Clinical course and characteristics of patients with coronavirus disease 2019 in Wuhan, China: a single-centered, retrospective, observational study. Aging, 12(16), 15946-15953. https://doi.org/10.18632/aging.103745
Liu Y, et al. Clinical Course and Characteristics of Patients With Coronavirus Disease 2019 in Wuhan, China: a Single-centered, Retrospective, Observational Study. Aging (Albany NY). 2020 08 24;12(16):15946-15953. PubMed PMID: 32833671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical course and characteristics of patients with coronavirus disease 2019 in Wuhan, China: a single-centered, retrospective, observational study. AU - Liu,Yanfang, AU - Liu,Lina, AU - Wang,Ye, AU - Du,Xinyang, AU - Ma,Hong, AU - Yao,Jing, Y1 - 2020/08/24/ PY - 2020/04/14/received PY - 2020/07/07/accepted PY - 2020/8/25/pubmed PY - 2020/9/17/medline PY - 2020/8/25/entrez KW - COVID-19 KW - SARS-CoV-2 KW - chronic diseases KW - infection KW - risk factors SP - 15946 EP - 15953 JF - Aging JO - Aging (Albany NY) VL - 12 IS - 16 N2 - BACKGROUND: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the virus responsible for the coronavirus disease 2019(COVID-19) pandemic. Despite the extensive studies aiming to understand the pathology of COVID-19, the clinicopathological characteristics and risk factors associated with COVID-19 remain mostly unclear. In this study, we assessed the clinical course and features of COVID-19 patients. FINDINGS: There were 59 patients (54.1%) that had no fever. One-hundred(91.7%) patients required oxygen therapy, which improved percutaneous oxygen saturation (SpO2). Seventy-two (66.1%) patients aged over 60; these patients were more likely to develop respiratory symptoms. Only 13(11.9%) patients were positive for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleic acid, and computed tomography (CT) findings. We found significant differences in age, respiratory symptoms, and heart rates between patients with and without underlying conditions. CONCLUSIONS: Our findings suggest that oxygen plays an important role in the treatment of COVID-19 patients and that age and underlying diseases are significant risk factors for COVID-19. Most COVID-19 patients have no fever, and CT provides higher detection rates than antibody- and nucleic acid-based detection methods. METHODS: We analyzed data from 109 confirmed COVID-19 cases. We compared the clinicopathological characteristic of patients stratified according to age and underlying diseases, as well as assessed the detection rates of different diagnostic methods. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/32833671/Clinical_course_and_characteristics_of_patients_with_coronavirus_disease_2019_in_Wuhan_China:_a_single_centered_retrospective_observational_study_ L2 - https://www.impactaging.com/full/12/15946 DB - PRIME DP - Unbound Medicine ER -