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Neurological manifestations of COVID-19 and other coronaviruses: A systematic review.
Neurol Psychiatry Brain Res. 2020 Sep; 37:27-32.NP

Abstract

Objective

To describe the main neurological manifestations related to coronavirus infection in humans.

Methodology

A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: "coronavirus" or "Sars-CoV-2" or "COVID-19" and "neurologic manifestations" or "neurological symptoms" or "meningitis" or "encephalitis" or "encephalopathy," following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

Seven studies were included. Neurological alterations after CoV infection may vary from 17.3% to 36.4% and, in the pediatric age range, encephalitis may be as frequent as respiratory disorders, affecting 11 % and 12 % of patients, respectively. The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. The main neurological alterations were headache (69; 16.8 %), dizziness (57, 13.9 %), altered consciousness (46; 11.2 %), vomiting (26; 6.3 %), epileptic crises (7; 1.7 %), neuralgia (5; 1.2 %), and ataxia (3; 0.7 %). The main presumed diagnoses were acute viral meningitis/encephalitis in 25 (6.1 %) patients, hypoxic encephalopathy in 23 (5.6 %) patients, acute cerebrovascular disease in 6 (1.4 %) patients, 1 (0.2 %) patient with possible acute disseminated encephalomyelitis, 1 (0.2 %) patient with acute necrotizing hemorrhagic encephalopathy, and 2 (1.4 %) patients with CoV related to Guillain-Barré syndrome.

Conclusion

Coronaviruses have important neurotropic potential and they cause neurological alterations that range from mild to severe. The main neurological manifestations found were headache, dizziness and altered consciousness.

Authors+Show Affiliations

Department of Neurosurgery, Hospital Universitário, Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco, Brazil.Faculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.Faculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.Faculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.Department of Neurosurgery, Hospital Universitário, Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco, Brazil.Faculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32834527

Citation

Correia, Alyne Oliveira, et al. "Neurological Manifestations of COVID-19 and Other Coronaviruses: a Systematic Review." Neurology, Psychiatry, and Brain Research, vol. 37, 2020, pp. 27-32.
Correia AO, Feitosa PWG, Moreira JLS, et al. Neurological manifestations of COVID-19 and other coronaviruses: A systematic review. Neurol Psychiatry Brain Res. 2020;37:27-32.
Correia, A. O., Feitosa, P. W. G., Moreira, J. L. S., Nogueira, S. Á. R., Fonseca, R. B., & Nobre, M. E. P. (2020). Neurological manifestations of COVID-19 and other coronaviruses: A systematic review. Neurology, Psychiatry, and Brain Research, 37, 27-32. https://doi.org/10.1016/j.npbr.2020.05.008
Correia AO, et al. Neurological Manifestations of COVID-19 and Other Coronaviruses: a Systematic Review. Neurol Psychiatry Brain Res. 2020;37:27-32. PubMed PMID: 32834527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological manifestations of COVID-19 and other coronaviruses: A systematic review. AU - Correia,Alyne Oliveira, AU - Feitosa,Pedro Walisson Gomes, AU - Moreira,Jorge Lucas de Sousa, AU - Nogueira,Samuel Átila Rodrigues, AU - Fonseca,Ricardo Brandão, AU - Nobre,Maria Elizabeth Pereira, Y1 - 2020/05/31/ PY - 2020/04/27/received PY - 2020/05/28/accepted PY - 2020/8/25/entrez PY - 2020/8/25/pubmed PY - 2020/8/25/medline KW - ACE2, angiotensin converting enzyme 2 KW - ADEM, acute disseminated encephalomyelitis KW - ANHE, acute necrotizing hemorrhagic encephalopathy KW - BBE, Bickerstaff’s encephalitis KW - COVID-19 KW - COVID-19, coronavirus disease 2019 KW - CoV, coronavirus KW - Coronavirus KW - DPP4, dipeptidil peptidase 4 KW - Encephalopathy KW - G-CSF, granulocyte colony stimulating factor (G-CSF) KW - GBS, Guillain-Barré syndrome KW - GM-CSF, granulocyte-macrophage colony-stimulating factor KW - HCoV, Human coronavirus KW - HCoV-229E, Human coronavirus 229E KW - HCoV-OC43, Human coronavirus OC43 KW - ICU, intensive care unit KW - IL, interleukin KW - MCP-1, monocyte chemoattractant protein-1 KW - MERS, Middle East respiratory syndrome KW - MERS-CoV, Middle East respiratory syndrome coronavirus KW - Neurologic manifestations KW - PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses KW - SARS, severe acute respiratory syndrome KW - SARS-CoV-2 KW - SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 KW - SARS‐CoV, severe acute respiratory syndrome coronavirus KW - βCoV, betacoronavírus SP - 27 EP - 32 JF - Neurology, psychiatry, and brain research JO - Neurol Psychiatry Brain Res VL - 37 N2 - Objective: To describe the main neurological manifestations related to coronavirus infection in humans. Methodology: A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: "coronavirus" or "Sars-CoV-2" or "COVID-19" and "neurologic manifestations" or "neurological symptoms" or "meningitis" or "encephalitis" or "encephalopathy," following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Seven studies were included. Neurological alterations after CoV infection may vary from 17.3% to 36.4% and, in the pediatric age range, encephalitis may be as frequent as respiratory disorders, affecting 11 % and 12 % of patients, respectively. The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. The main neurological alterations were headache (69; 16.8 %), dizziness (57, 13.9 %), altered consciousness (46; 11.2 %), vomiting (26; 6.3 %), epileptic crises (7; 1.7 %), neuralgia (5; 1.2 %), and ataxia (3; 0.7 %). The main presumed diagnoses were acute viral meningitis/encephalitis in 25 (6.1 %) patients, hypoxic encephalopathy in 23 (5.6 %) patients, acute cerebrovascular disease in 6 (1.4 %) patients, 1 (0.2 %) patient with possible acute disseminated encephalomyelitis, 1 (0.2 %) patient with acute necrotizing hemorrhagic encephalopathy, and 2 (1.4 %) patients with CoV related to Guillain-Barré syndrome. Conclusion: Coronaviruses have important neurotropic potential and they cause neurological alterations that range from mild to severe. The main neurological manifestations found were headache, dizziness and altered consciousness. SN - 0941-9500 UR - https://www.unboundmedicine.com/medline/citation/32834527/Neurological_manifestations_of_COVID_19_and_other_coronaviruses:_A_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0941-9500(20)30071-3 DB - PRIME DP - Unbound Medicine ER -
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