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Lifting the mask on neurological manifestations of COVID-19.
Nat Rev Neurol. 2020 11; 16(11):636-644.NR

Abstract

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In particular, virus-related neurological manifestations are being reported more and more frequently in the scientific literature. In this article, we review the literature on the association between COVID-19 and neurological manifestations, present evidence from preclinical research suggesting that SARS-CoV-2 could be responsible for many of these manifestations, and summarize the biological pathways that could underlie each neurological symptom. Understanding the mechanisms that lead to neurological manifestations in patients with COVID-19 and how these manifestations correlate with clinical outcomes will be instrumental in guiding the optimal use of targeted therapeutic strategies.

Authors+Show Affiliations

Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy. alessandro.pezzini@unibs.it.Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32839585

Citation

Pezzini, Alessandro, and Alessandro Padovani. "Lifting the Mask On Neurological Manifestations of COVID-19." Nature Reviews. Neurology, vol. 16, no. 11, 2020, pp. 636-644.
Pezzini A, Padovani A. Lifting the mask on neurological manifestations of COVID-19. Nat Rev Neurol. 2020;16(11):636-644.
Pezzini, A., & Padovani, A. (2020). Lifting the mask on neurological manifestations of COVID-19. Nature Reviews. Neurology, 16(11), 636-644. https://doi.org/10.1038/s41582-020-0398-3
Pezzini A, Padovani A. Lifting the Mask On Neurological Manifestations of COVID-19. Nat Rev Neurol. 2020;16(11):636-644. PubMed PMID: 32839585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifting the mask on neurological manifestations of COVID-19. AU - Pezzini,Alessandro, AU - Padovani,Alessandro, Y1 - 2020/08/24/ PY - 2020/07/28/accepted PY - 2020/8/26/pubmed PY - 2020/11/5/medline PY - 2020/8/26/entrez SP - 636 EP - 644 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 16 IS - 11 N2 - As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In particular, virus-related neurological manifestations are being reported more and more frequently in the scientific literature. In this article, we review the literature on the association between COVID-19 and neurological manifestations, present evidence from preclinical research suggesting that SARS-CoV-2 could be responsible for many of these manifestations, and summarize the biological pathways that could underlie each neurological symptom. Understanding the mechanisms that lead to neurological manifestations in patients with COVID-19 and how these manifestations correlate with clinical outcomes will be instrumental in guiding the optimal use of targeted therapeutic strategies. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/32839585/Lifting_the_mask_on_neurological_manifestations_of_COVID_19_ L2 - https://doi.org/10.1038/s41582-020-0398-3 DB - PRIME DP - Unbound Medicine ER -