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Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study.
J Child Psychol Psychiatry. 2021 04; 62(4):404-413.JC

Abstract

BACKGROUND

There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders.

METHODS

Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years.

RESULTS

Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD.

CONCLUSIONS

The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD.

Authors+Show Affiliations

Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Institute of Mental Health, Laval University, Québec, QC, Canada.Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland.Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32841378

Citation

Rudaz, Dominique, et al. "Psychopathological Precursors of the Onset of Mood Disorders in Offspring of Parents With and Without Mood Disorders: Results of a 13-year Prospective Cohort High-risk Study." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 62, no. 4, 2021, pp. 404-413.
Rudaz D, Vandeleur CL, Gholam M, et al. Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study. J Child Psychol Psychiatry. 2021;62(4):404-413.
Rudaz, D., Vandeleur, C. L., Gholam, M., Castelao, E., Strippoli, M. F., Marquet, P., Aubry, J. M., Merikangas, K. R., & Preisig, M. (2021). Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 62(4), 404-413. https://doi.org/10.1111/jcpp.13307
Rudaz D, et al. Psychopathological Precursors of the Onset of Mood Disorders in Offspring of Parents With and Without Mood Disorders: Results of a 13-year Prospective Cohort High-risk Study. J Child Psychol Psychiatry. 2021;62(4):404-413. PubMed PMID: 32841378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study. AU - Rudaz,Dominique, AU - Vandeleur,Caroline L, AU - Gholam,Mehdi, AU - Castelao,Enrique, AU - Strippoli,Marie-Pierre F, AU - Marquet,Pierre, AU - Aubry,Jean-Michel, AU - Merikangas,Kathleen R, AU - Preisig,Martin, Y1 - 2020/08/25/ PY - 2020/07/07/revised PY - 2019/11/18/received PY - 2020/07/08/accepted PY - 2020/8/26/pubmed PY - 2021/10/16/medline PY - 2020/8/26/entrez KW - Mood disorders KW - anxiety disorders KW - drug misuse KW - offspring of bipolar parents KW - offspring of depressed parents KW - precursors SP - 404 EP - 413 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 62 IS - 4 N2 - BACKGROUND: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. METHODS: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. RESULTS: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. CONCLUSIONS: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD. SN - 1469-7610 UR - https://www.unboundmedicine.com/medline/citation/32841378/Psychopathological_precursors_of_the_onset_of_mood_disorders_in_offspring_of_parents_with_and_without_mood_disorders:_results_of_a_13_year_prospective_cohort_high_risk_study_ L2 - https://doi.org/10.1111/jcpp.13307 DB - PRIME DP - Unbound Medicine ER -