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Cytokines and COVID-19: friends or foes?
Hum Vaccin Immunother. 2020 Oct 02; 16(10):2363-2365.HV

Abstract

The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Authors+Show Affiliations

Rokni M
Department of Immunology, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.
Hamblin MR
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN) , Boston, MA, USA.
Rezaei N
Department of Immunology, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN) , Tehran, Iran. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences , Tehran, Iran.

MeSH

Antibodies, Monoclonal, HumanizedBetacoronavirusCOVID-19Coronavirus InfectionsCytokine Receptor gp130Cytokine Release SyndromeCytokinesHumansImmunosuppressive AgentsInflammationPandemicsPneumonia, ViralSARS-CoV-2Severe Acute Respiratory Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32841579

Citation

Rokni, Mohsen, et al. "Cytokines and COVID-19: Friends or Foes?" Human Vaccines & Immunotherapeutics, vol. 16, no. 10, 2020, pp. 2363-2365.
Rokni M, Hamblin MR, Rezaei N. Cytokines and COVID-19: friends or foes? Hum Vaccin Immunother. 2020;16(10):2363-2365.
Rokni, M., Hamblin, M. R., & Rezaei, N. (2020). Cytokines and COVID-19: friends or foes? Human Vaccines & Immunotherapeutics, 16(10), 2363-2365. https://doi.org/10.1080/21645515.2020.1799669
Rokni M, Hamblin MR, Rezaei N. Cytokines and COVID-19: Friends or Foes. Hum Vaccin Immunother. 2020 Oct 2;16(10):2363-2365. PubMed PMID: 32841579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokines and COVID-19: friends or foes? AU - Rokni,Mohsen, AU - Hamblin,Michael R, AU - Rezaei,Nima, Y1 - 2020/08/25/ PY - 2020/8/26/pubmed PY - 2020/11/18/medline PY - 2020/8/26/entrez KW - COVID-19 KW - Cytokine storm KW - chemokines KW - pro-inflammatory cytokines KW - severe acute respiratory syndrome coronavirus 2 SP - 2363 EP - 2365 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 16 IS - 10 N2 - The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/32841579/Cytokines_and_COVID_19:_friends_or_foes DB - PRIME DP - Unbound Medicine ER -