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Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China.
Respiration. 2020; 99(8):649-657.R

Abstract

BACKGROUND

A new virus broke out in Wuhan, Hubei, China, that was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical characteristics of severe pneumonia caused by SARS-CoV-2 are still not clear.

OBJECTIVES

The aim of this study was to explore the clinical characteristics and risk factors of severe pneumonia caused by the SARS-CoV-2 in Wuhan, China.

METHODS

The study included patients hospitalized at the Central Hospital of Wuhan who were diagnosed with COVID-19. Clinical features, chronic comorbidities, demographic data, laboratory examinations, and chest computed tomography (CT) scans were reviewed through electronic medical records. SPSS was used for data analysis to explore the clinical characteristics and risk factors of patients with severe pneumonia caused by SARS-CoV-2.

RESULTS

A total of 110 patients diagnosed with COVID-19 were included in the study, including 38 with severe pneumonia and 72 with nonsevere pneumonia. Statistical analysis showed that advanced age, increased D-Dimer, and decreased lymphocytes were characteristics of the patients with severe pneumonia. Moreover, in the early stage of the disease, chest CT scans of patients with severe pneumonia showed that the illness can progress rapidly.

CONCLUSIONS

Advanced age, decreased lymphocytes, and D-Dimer elevation are important characteristics of patients with severe COVID-19. Clinicians should focus on these characteristics to identify high-risk patients at an early stage.

Authors+Show Affiliations

Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China, gszxyy123@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32841948

Citation

Wang, Yafei, et al. "Clinical Characteristics of Patients With Severe Pneumonia Caused By the SARS-CoV-2 in Wuhan, China." Respiration; International Review of Thoracic Diseases, vol. 99, no. 8, 2020, pp. 649-657.
Wang Y, Zhou Y, Yang Z, et al. Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China. Respiration. 2020;99(8):649-657.
Wang, Y., Zhou, Y., Yang, Z., Xia, D., Hu, Y., & Geng, S. (2020). Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China. Respiration; International Review of Thoracic Diseases, 99(8), 649-657. https://doi.org/10.1159/000507940
Wang Y, et al. Clinical Characteristics of Patients With Severe Pneumonia Caused By the SARS-CoV-2 in Wuhan, China. Respiration. 2020;99(8):649-657. PubMed PMID: 32841948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China. AU - Wang,Yafei, AU - Zhou,Ying, AU - Yang,Zhen, AU - Xia,Dongping, AU - Hu,Yi, AU - Geng,Shuang, Y1 - 2020/08/25/ PY - 2020/02/22/received PY - 2020/04/15/accepted PY - 2020/8/26/pubmed PY - 2020/10/2/medline PY - 2020/8/26/entrez KW - D-Dimer KW - Lymphocyte KW - SARS-CoV-2 KW - Severe pneumonia SP - 649 EP - 657 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 99 IS - 8 N2 - BACKGROUND: A new virus broke out in Wuhan, Hubei, China, that was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical characteristics of severe pneumonia caused by SARS-CoV-2 are still not clear. OBJECTIVES: The aim of this study was to explore the clinical characteristics and risk factors of severe pneumonia caused by the SARS-CoV-2 in Wuhan, China. METHODS: The study included patients hospitalized at the Central Hospital of Wuhan who were diagnosed with COVID-19. Clinical features, chronic comorbidities, demographic data, laboratory examinations, and chest computed tomography (CT) scans were reviewed through electronic medical records. SPSS was used for data analysis to explore the clinical characteristics and risk factors of patients with severe pneumonia caused by SARS-CoV-2. RESULTS: A total of 110 patients diagnosed with COVID-19 were included in the study, including 38 with severe pneumonia and 72 with nonsevere pneumonia. Statistical analysis showed that advanced age, increased D-Dimer, and decreased lymphocytes were characteristics of the patients with severe pneumonia. Moreover, in the early stage of the disease, chest CT scans of patients with severe pneumonia showed that the illness can progress rapidly. CONCLUSIONS: Advanced age, decreased lymphocytes, and D-Dimer elevation are important characteristics of patients with severe COVID-19. Clinicians should focus on these characteristics to identify high-risk patients at an early stage. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/32841948/Clinical_Characteristics_of_Patients_with_Severe_Pneumonia_Caused_by_the_SARS_CoV_2_in_Wuhan_China_ L2 - https://www.karger.com?DOI=10.1159/000507940 DB - PRIME DP - Unbound Medicine ER -