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Could Vitamins Help in the Fight Against COVID-19?
Nutrients. 2020 Aug 23; 12(9)N

Abstract

There are limited proven therapeutic options for the prevention and treatment of COVID-19. The role of vitamin and mineral supplementation or "immunonutrition" has previously been explored in a number of clinical trials in intensive care settings, and there are several hypotheses to support their routine use. The aim of this narrative review was to investigate whether vitamin supplementation is beneficial in COVID-19. A systematic search strategy with a narrative literature summary was designed, using the Medline, EMBASE, Cochrane Trials Register, WHO International Clinical Trial Registry, and Nexis media databases. The immune-mediating, antioxidant and antimicrobial roles of vitamins A to E were explored and their potential role in the fight against COVID-19 was evaluated. The major topics extracted for narrative synthesis were physiological and immunological roles of each vitamin, their role in respiratory infections, acute respiratory distress syndrome (ARDS), and COVID-19. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis. Although there are currently no published clinical trials due to the novelty of SARS-CoV-2 infection, there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups. The final outcomes of ongoing trials of vitamin supplementation are awaited with interest.

Authors+Show Affiliations

Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.Institute for Optimum Nutrition, Ambassador House, Paradise Road, Richmond TW9 1SQ, UK.Institute of Life Sciences 1, Swansea University Medical School, Swansea University, Swansea SA2 8PY, UK.Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA28PY, UK. Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA66NL, UK.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32842513

Citation

Jovic, Thomas H., et al. "Could Vitamins Help in the Fight Against COVID-19?" Nutrients, vol. 12, no. 9, 2020.
Jovic TH, Ali SR, Ibrahim N, et al. Could Vitamins Help in the Fight Against COVID-19? Nutrients. 2020;12(9).
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19? Nutrients, 12(9). https://doi.org/10.3390/nu12092550
Jovic TH, et al. Could Vitamins Help in the Fight Against COVID-19. Nutrients. 2020 Aug 23;12(9) PubMed PMID: 32842513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could Vitamins Help in the Fight Against COVID-19? AU - Jovic,Thomas H, AU - Ali,Stephen R, AU - Ibrahim,Nader, AU - Jessop,Zita M, AU - Tarassoli,Sam P, AU - Dobbs,Thomas D, AU - Holford,Patrick, AU - Thornton,Catherine A, AU - Whitaker,Iain S, Y1 - 2020/08/23/ PY - 2020/08/03/received PY - 2020/08/19/revised PY - 2020/08/20/accepted PY - 2020/8/27/entrez PY - 2020/8/28/pubmed PY - 2020/9/9/medline KW - COVID-19 KW - SARS-CoV-2 KW - immunonutrition KW - supplementation KW - vitamin JF - Nutrients JO - Nutrients VL - 12 IS - 9 N2 - There are limited proven therapeutic options for the prevention and treatment of COVID-19. The role of vitamin and mineral supplementation or "immunonutrition" has previously been explored in a number of clinical trials in intensive care settings, and there are several hypotheses to support their routine use. The aim of this narrative review was to investigate whether vitamin supplementation is beneficial in COVID-19. A systematic search strategy with a narrative literature summary was designed, using the Medline, EMBASE, Cochrane Trials Register, WHO International Clinical Trial Registry, and Nexis media databases. The immune-mediating, antioxidant and antimicrobial roles of vitamins A to E were explored and their potential role in the fight against COVID-19 was evaluated. The major topics extracted for narrative synthesis were physiological and immunological roles of each vitamin, their role in respiratory infections, acute respiratory distress syndrome (ARDS), and COVID-19. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis. Although there are currently no published clinical trials due to the novelty of SARS-CoV-2 infection, there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups. The final outcomes of ongoing trials of vitamin supplementation are awaited with interest. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32842513/Could_Vitamins_Help_in_the_Fight_Against_COVID_19 L2 - https://www.mdpi.com/resolver?pii=nu12092550 DB - PRIME DP - Unbound Medicine ER -