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Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development.
Virus Res. 2020 10 15; 288:198141.VR

Abstract

The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are infected, and over 781,135 people have died due to this deadly virus. In the USA alone, over 5,482,602 people are currently infected, and more than 171,823 people have died. SARS-CoV-2 has shown a higher infectivity rate and a more extended incubation period as compared to previous coronaviruses. SARS-CoV-2 binds much more strongly than SARS-CoV to the same host receptor, angiotensin-converting enzyme 2 (ACE2). Previously, several methods to develop a vaccine against SARS-CoV or MERS-CoV have been tried with limited success. Since SARS-CoV-2 uses the spike (S) protein for entry to the host cell, it is one of the most preferred targets for making vaccines or therapeutics against SARS-CoV-2. In this review, we have summarised the characteristics of the S protein, as well as the different approaches being used for the development of vaccines and/or therapeutics based on the S protein.

Authors+Show Affiliations

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, 1 University Place, Rensselaer, NY 12144, USA. Electronic address: Hongmin.li@health.ny.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

32846196

Citation

Samrat, Subodh Kumar, et al. "Prospect of SARS-CoV-2 Spike Protein: Potential Role in Vaccine and Therapeutic Development." Virus Research, vol. 288, 2020, p. 198141.
Samrat SK, Tharappel AM, Li Z, et al. Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development. Virus Res. 2020;288:198141.
Samrat, S. K., Tharappel, A. M., Li, Z., & Li, H. (2020). Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development. Virus Research, 288, 198141. https://doi.org/10.1016/j.virusres.2020.198141
Samrat SK, et al. Prospect of SARS-CoV-2 Spike Protein: Potential Role in Vaccine and Therapeutic Development. Virus Res. 2020 10 15;288:198141. PubMed PMID: 32846196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development. AU - Samrat,Subodh Kumar, AU - Tharappel,Anil M, AU - Li,Zhong, AU - Li,Hongmin, Y1 - 2020/08/23/ PY - 2020/06/19/received PY - 2020/08/19/revised PY - 2020/08/20/accepted PY - 2020/8/28/pubmed PY - 2020/10/8/medline PY - 2020/8/27/entrez KW - COVID-19 KW - SARS-CoV-2 KW - Spike protein KW - Therapeutic KW - Vaccine SP - 198141 EP - 198141 JF - Virus research JO - Virus Res VL - 288 N2 - The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are infected, and over 781,135 people have died due to this deadly virus. In the USA alone, over 5,482,602 people are currently infected, and more than 171,823 people have died. SARS-CoV-2 has shown a higher infectivity rate and a more extended incubation period as compared to previous coronaviruses. SARS-CoV-2 binds much more strongly than SARS-CoV to the same host receptor, angiotensin-converting enzyme 2 (ACE2). Previously, several methods to develop a vaccine against SARS-CoV or MERS-CoV have been tried with limited success. Since SARS-CoV-2 uses the spike (S) protein for entry to the host cell, it is one of the most preferred targets for making vaccines or therapeutics against SARS-CoV-2. In this review, we have summarised the characteristics of the S protein, as well as the different approaches being used for the development of vaccines and/or therapeutics based on the S protein. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/32846196/Prospect_of_SARS_CoV_2_spike_protein:_Potential_role_in_vaccine_and_therapeutic_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(20)31048-0 DB - PRIME DP - Unbound Medicine ER -