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Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China.
Medicine (Baltimore). 2020 Aug 21; 99(34):e21824.M

Abstract

In December 2019, a cluster of coronavirus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The present study was conducted to report the clinical characteristics of 201 COVID-19 patients in Changsha, China, a city outside of Wuhan. All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by April 28, 2020. The median age of the patients was 45 years (IQR 34-59). About half (50.7%) of the patients were male, and most of the infected patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever (125 [62.2%]), dry cough (118 [58.7%]), fatigue (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU patients had depressed white blood cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time (PT). Moreover, higher plasma levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group. In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency, hepatic injury, and kidney injury should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

Authors+Show Affiliations

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan.Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang. Department of Anesthesiology, The Second Xiangya Hospital, Central South University.Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan.Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan.Department of Respiratory Medicine, The First Hospital of Changsha City, Changsha, Hunan, China.Department of Respiratory Medicine, The First Hospital of Changsha City, Changsha, Hunan, China.Department of Respiratory Medicine, The First Hospital of Changsha City, Changsha, Hunan, China.Department of Respiratory Medicine, The First Hospital of Changsha City, Changsha, Hunan, China.Department of Respiratory Medicine, The First Hospital of Changsha City, Changsha, Hunan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32846825

Citation

Zhou, Jian, et al. "Epidemiological and Clinical Features of 201 COVID-19 Patients in Changsha City, Hunan, China." Medicine, vol. 99, no. 34, 2020, pp. e21824.
Zhou J, Sun J, Cao Z, et al. Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China. Medicine (Baltimore). 2020;99(34):e21824.
Zhou, J., Sun, J., Cao, Z., Wang, W., Huang, K., Zheng, F., Xie, Y., Jiang, D., & Zhou, Z. (2020). Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China. Medicine, 99(34), e21824. https://doi.org/10.1097/MD.0000000000021824
Zhou J, et al. Epidemiological and Clinical Features of 201 COVID-19 Patients in Changsha City, Hunan, China. Medicine (Baltimore). 2020 Aug 21;99(34):e21824. PubMed PMID: 32846825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China. AU - Zhou,Jian, AU - Sun,Jingjing, AU - Cao,Ziqin, AU - Wang,Wanchun, AU - Huang,Kang, AU - Zheng,Fang, AU - Xie,Yuanlin, AU - Jiang,Dixuan, AU - Zhou,Zhiguo, PY - 2020/8/28/entrez PY - 2020/8/28/pubmed PY - 2020/9/15/medline SP - e21824 EP - e21824 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 34 N2 - In December 2019, a cluster of coronavirus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The present study was conducted to report the clinical characteristics of 201 COVID-19 patients in Changsha, China, a city outside of Wuhan. All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by April 28, 2020. The median age of the patients was 45 years (IQR 34-59). About half (50.7%) of the patients were male, and most of the infected patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever (125 [62.2%]), dry cough (118 [58.7%]), fatigue (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU patients had depressed white blood cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time (PT). Moreover, higher plasma levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group. In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency, hepatic injury, and kidney injury should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/32846825/Epidemiological_and_clinical_features_of_201_COVID_19_patients_in_Changsha_city_Hunan_China_ L2 - https://doi.org/10.1097/MD.0000000000021824 DB - PRIME DP - Unbound Medicine ER -