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Expression of class II MHC gene products by macrophages in human uteroplacental tissue.
Immunology. 1988 Apr; 63(4):707-14.I

Abstract

The expression of class II MHC determinants by fetal and maternal macrophages in human uteroplacental tissues was examined with monoclonal antibodies directed against HLA-DR, DP and DQ antigens. Maternal macrophages in early and full-term pregnancy decidua were HLA-DR positive, and a substantial proportion also expressed DP and DQ antigens. Fetal macrophages in chorionic villous stroma in first-trimester pregnancy were rarely HLA-DR positive, and DQ and DP antigens were never expressed. In term placental tissues, groups of villous stromal macrophages were HLA-DR positive, as were fetal macrophages within amniotic mesenchyme. In contrast, DP and DQ antigens were detected on a small minority of fetal macrophages in term placental tissues. DP and DQ antigens were not detected in the absence of DR antigens.

Authors+Show Affiliations

Department of Pathology, University of Leeds, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3284818

Citation

Bulmer, J N., et al. "Expression of Class II MHC Gene Products By Macrophages in Human Uteroplacental Tissue." Immunology, vol. 63, no. 4, 1988, pp. 707-14.
Bulmer JN, Morrison L, Smith JC. Expression of class II MHC gene products by macrophages in human uteroplacental tissue. Immunology. 1988;63(4):707-14.
Bulmer, J. N., Morrison, L., & Smith, J. C. (1988). Expression of class II MHC gene products by macrophages in human uteroplacental tissue. Immunology, 63(4), 707-14.
Bulmer JN, Morrison L, Smith JC. Expression of Class II MHC Gene Products By Macrophages in Human Uteroplacental Tissue. Immunology. 1988;63(4):707-14. PubMed PMID: 3284818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of class II MHC gene products by macrophages in human uteroplacental tissue. AU - Bulmer,J N, AU - Morrison,L, AU - Smith,J C, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 707 EP - 14 JF - Immunology JO - Immunology VL - 63 IS - 4 N2 - The expression of class II MHC determinants by fetal and maternal macrophages in human uteroplacental tissues was examined with monoclonal antibodies directed against HLA-DR, DP and DQ antigens. Maternal macrophages in early and full-term pregnancy decidua were HLA-DR positive, and a substantial proportion also expressed DP and DQ antigens. Fetal macrophages in chorionic villous stroma in first-trimester pregnancy were rarely HLA-DR positive, and DQ and DP antigens were never expressed. In term placental tissues, groups of villous stromal macrophages were HLA-DR positive, as were fetal macrophages within amniotic mesenchyme. In contrast, DP and DQ antigens were detected on a small minority of fetal macrophages in term placental tissues. DP and DQ antigens were not detected in the absence of DR antigens. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/3284818/Expression_of_class_II_MHC_gene_products_by_macrophages_in_human_uteroplacental_tissue_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3284818/ DB - PRIME DP - Unbound Medicine ER -