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The effect of menopause on metabolic syndrome: cross-sectional results from the Canadian Longitudinal Study on Aging.
Menopause. 2020 09; 27(9):999-1009.M

Abstract

OBJECTIVES

Data were examined from women surveyed in the Canadian Longitudinal Study on Aging to evaluate whether menopause is an independent risk factor for the development of metabolic syndrome (MetS) or its components, including hypertension, central obesity, dyslipidemia, or elevated glycated hemoglobin.

METHODS

We conducted a cross-sectional analysis of women aged 45-85 years old that participated in the baseline data of the Canadian Longitudinal Study on Aging Comprehensive Cohort collected from 2012 to 2015. Modified Poisson regression with robust error variance was used to estimate the crude and adjusted relative risks (aRRs) of MetS in postmenopausal women compared to premenopausal women.

RESULTS

Among 12,611 women analyzed, 10,035 (79.6%) had undergone menopause and 2,576 (20.4%) were premenopausal. Postmenopausal women were more likely to meet criteria for MetS compared to premenopausal women (32.6% vs 20.5%, P < 0.001). Using the MetS criteria with a lower waist circumference threshold, the prevalence of MetS was higher at 38.2% among postmenopausal women and 23.2% among premenopausal women (P < 0.001). After adjusting for age, body mass index, and other covariates, the occurrence of menopause was not associated with a significantly higher relative risk of MetS, using the unified criteria for MetS (aRR 1.09 [95% CI: 0.99-1.19]). Women with menopause had a significantly higher relative risk of MetS when using criteria with a lower waist circumference (aRR 1.10 [95% CI: 1.01-1.19]). Menopause was also associated with a higher risk of impaired glucose tolerance (aRR 1.42 [95% CI: 1.26-1.59]), elevated blood pressure (aRR 1.12 [95% CI: 1.03-1.21]), and elevated triglycerides (aRR 1.17 [95% CI: 1.08-1.26]).

CONCLUSION

Menopause is associated with an increased risk of MetS, independent of age. Lifestyle interventions targeted at women with MetS are known to prevent type 2 diabetes mellitus and cardiovascular risk. Perimenopause may be an important preventative care opportunity to assess metabolic risk factors and improve health and longevity of Canadian women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Ontario, Canada.Epi Methods Consulting, Toronto, Ontario, Canada.Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Ontario, Canada.Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32852451

Citation

Christakis, Marie K., et al. "The Effect of Menopause On Metabolic Syndrome: Cross-sectional Results From the Canadian Longitudinal Study On Aging." Menopause (New York, N.Y.), vol. 27, no. 9, 2020, pp. 999-1009.
Christakis MK, Hasan H, De Souza LR, et al. The effect of menopause on metabolic syndrome: cross-sectional results from the Canadian Longitudinal Study on Aging. Menopause. 2020;27(9):999-1009.
Christakis, M. K., Hasan, H., De Souza, L. R., & Shirreff, L. (2020). The effect of menopause on metabolic syndrome: cross-sectional results from the Canadian Longitudinal Study on Aging. Menopause (New York, N.Y.), 27(9), 999-1009. https://doi.org/10.1097/GME.0000000000001575
Christakis MK, et al. The Effect of Menopause On Metabolic Syndrome: Cross-sectional Results From the Canadian Longitudinal Study On Aging. Menopause. 2020;27(9):999-1009. PubMed PMID: 32852451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of menopause on metabolic syndrome: cross-sectional results from the Canadian Longitudinal Study on Aging. AU - Christakis,Marie K, AU - Hasan,Haroon, AU - De Souza,Leanne R, AU - Shirreff,Lindsay, PY - 2020/8/28/entrez PY - 2020/8/28/pubmed PY - 2021/4/28/medline SP - 999 EP - 1009 JF - Menopause (New York, N.Y.) JO - Menopause VL - 27 IS - 9 N2 - OBJECTIVES: Data were examined from women surveyed in the Canadian Longitudinal Study on Aging to evaluate whether menopause is an independent risk factor for the development of metabolic syndrome (MetS) or its components, including hypertension, central obesity, dyslipidemia, or elevated glycated hemoglobin. METHODS: We conducted a cross-sectional analysis of women aged 45-85 years old that participated in the baseline data of the Canadian Longitudinal Study on Aging Comprehensive Cohort collected from 2012 to 2015. Modified Poisson regression with robust error variance was used to estimate the crude and adjusted relative risks (aRRs) of MetS in postmenopausal women compared to premenopausal women. RESULTS: Among 12,611 women analyzed, 10,035 (79.6%) had undergone menopause and 2,576 (20.4%) were premenopausal. Postmenopausal women were more likely to meet criteria for MetS compared to premenopausal women (32.6% vs 20.5%, P < 0.001). Using the MetS criteria with a lower waist circumference threshold, the prevalence of MetS was higher at 38.2% among postmenopausal women and 23.2% among premenopausal women (P < 0.001). After adjusting for age, body mass index, and other covariates, the occurrence of menopause was not associated with a significantly higher relative risk of MetS, using the unified criteria for MetS (aRR 1.09 [95% CI: 0.99-1.19]). Women with menopause had a significantly higher relative risk of MetS when using criteria with a lower waist circumference (aRR 1.10 [95% CI: 1.01-1.19]). Menopause was also associated with a higher risk of impaired glucose tolerance (aRR 1.42 [95% CI: 1.26-1.59]), elevated blood pressure (aRR 1.12 [95% CI: 1.03-1.21]), and elevated triglycerides (aRR 1.17 [95% CI: 1.08-1.26]). CONCLUSION: Menopause is associated with an increased risk of MetS, independent of age. Lifestyle interventions targeted at women with MetS are known to prevent type 2 diabetes mellitus and cardiovascular risk. Perimenopause may be an important preventative care opportunity to assess metabolic risk factors and improve health and longevity of Canadian women. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/32852451/The_effect_of_menopause_on_metabolic_syndrome:_cross_sectional_results_from_the_Canadian_Longitudinal_Study_on_Aging_ L2 - https://doi.org/10.1097/GME.0000000000001575 DB - PRIME DP - Unbound Medicine ER -