TY - JOUR T1 - Reaction of human smooth muscle autoantibody with gastric parietal cells: a pitfall in the diagnosis of parietal cell autoantibody. AU - Ceredig,R, AU - Toh,B H, PY - 1977/7/1/pubmed PY - 1977/7/1/medline PY - 1977/7/1/entrez SP - 666 EP - 70 JF - Journal of clinical pathology JO - J Clin Pathol VL - 30 IS - 7 N2 - Thirteen smooth muscle antibody (SMA) sera obtained from patients with active chronic hepatitis were examined for immunofluorescence reactivity with gastric mucosal cells. Eight out of 13 sera stained the cytoplasm of gastric parietal cells in a pattern indistinguishable from that obtained with parietal cell autoantibody (PCA). The staining reaction was localised to parietal cells by the demonstration that the same cells stained with both SMA and PCA in double immunofluorescent tests. The SMA staining intensity for parietal cells was weaker than that for smooth muscle. Specificity of the staining reaction for actin was established by the observation that parietal cell staining by SMA was inhibition by serum absorption with skeletal muscle F-actin but not by a microsomal fraction derived from gastric mucosa. SN - 0021-9746 UR - https://www.unboundmedicine.com/medline/citation/328539/Reaction_of_human_smooth_muscle_autoantibody_with_gastric_parietal_cells:_a_pitfall_in_the_diagnosis_of_parietal_cell_autoantibody_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&pmid=328539 DB - PRIME DP - Unbound Medicine ER -