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Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China.
Aging (Albany NY). 2020 08 28; 12(16):15938-15945.A

Abstract

BACKGROUND

Previous work has described acute liver injury (ALI) in coronavirus disease 2019 (COVID-19) pneumonia patients, However, there is limited analyses available investigating chronic liver disease (CLD) in COVID-19 patients. This study aimed to investigate clinical characteristics and outcomes of CLD confirmed in COVID-19 patients.

RESULTS

A total of 104 cases (each group containing 52 patients) were analyzed in this study. The CLD group showed an average of 14 (10.0~21.2) length of stay (LOS) days, compared to the group without CLD that only showed an average of 12.5 (10~16) LOS days (Relative Risk [RR] = 1.34, 95% CI (1.22~1.48), P<0.001; Adjusted Relative Risk was 1.24 (95% CI: 1.12~1.39)). The CLD group contained a higher mortality rate and slight liver injury. Furthermore, COX regression model analyses suggested that the neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of mortality risk (P < 0.001) in the CLD group. Additionally, a high NLR significantly correlated with a shorter overall survival (P <0.001).

CONCLUSIONS

COVID-19 patients also diagnosed with CLD suffered longer LOS, slight liver injuries and a higher mortality when compared to COVID-19 patients without CLD. The NLR was an independent risk factor for in-hospital deaths. Increased expression of NLR was an indicator of poor prognosis in COVID-19 patients with CLD. Thus, COVID-19 patients diagnosed with CLD and who show a higher NLR need additional care.

METHODS

A retrospective cohort study was performed at the Wuhan Jin Yin-tan Hospital from February 2, 2020 to April 2, 2020. COVID-19 patients diagnosed with CLD or not diagnosed with CLD were enrolled in this study. The clinical characteristics and outcomes of these patients were compared.

Authors+Show Affiliations

Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Pulmonary Diseases and Tuberculosis, Jin Yin-Tan Hospital, Wuhan, China.Department of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Neurology, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, China.Department of Emergency Management, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.Department of Surgical, The Fujian Pinghe County People's Hospital, Zhangzhou, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32855361

Citation

Li, Chaowei, et al. "Clinical Characteristics of Chronic Liver Disease With Coronavirus Disease 2019 (COVID-19): a Cohort Study in Wuhan, China." Aging, vol. 12, no. 16, 2020, pp. 15938-15945.
Li C, Chen Q, Wang J, et al. Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China. Aging (Albany NY). 2020;12(16):15938-15945.
Li, C., Chen, Q., Wang, J., Lin, H., Lin, Y., Lin, J., Peng, F., Chen, J., & Yang, Z. (2020). Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China. Aging, 12(16), 15938-15945. https://doi.org/10.18632/aging.103632
Li C, et al. Clinical Characteristics of Chronic Liver Disease With Coronavirus Disease 2019 (COVID-19): a Cohort Study in Wuhan, China. Aging (Albany NY). 2020 08 28;12(16):15938-15945. PubMed PMID: 32855361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China. AU - Li,Chaowei, AU - Chen,Qingshi, AU - Wang,Jianwen, AU - Lin,Huasong, AU - Lin,Yalan, AU - Lin,Jinhuang, AU - Peng,Fangzhan, AU - Chen,Jiangmu, AU - Yang,Zhirong, Y1 - 2020/08/28/ PY - 2020/05/06/received PY - 2020/06/22/accepted PY - 2020/8/29/pubmed PY - 2020/9/17/medline PY - 2020/8/29/entrez KW - COVID-19 KW - LOS KW - NLR KW - mortality KW - severity SP - 15938 EP - 15945 JF - Aging JO - Aging (Albany NY) VL - 12 IS - 16 N2 - BACKGROUND: Previous work has described acute liver injury (ALI) in coronavirus disease 2019 (COVID-19) pneumonia patients, However, there is limited analyses available investigating chronic liver disease (CLD) in COVID-19 patients. This study aimed to investigate clinical characteristics and outcomes of CLD confirmed in COVID-19 patients. RESULTS: A total of 104 cases (each group containing 52 patients) were analyzed in this study. The CLD group showed an average of 14 (10.0~21.2) length of stay (LOS) days, compared to the group without CLD that only showed an average of 12.5 (10~16) LOS days (Relative Risk [RR] = 1.34, 95% CI (1.22~1.48), P<0.001; Adjusted Relative Risk was 1.24 (95% CI: 1.12~1.39)). The CLD group contained a higher mortality rate and slight liver injury. Furthermore, COX regression model analyses suggested that the neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of mortality risk (P < 0.001) in the CLD group. Additionally, a high NLR significantly correlated with a shorter overall survival (P <0.001). CONCLUSIONS: COVID-19 patients also diagnosed with CLD suffered longer LOS, slight liver injuries and a higher mortality when compared to COVID-19 patients without CLD. The NLR was an independent risk factor for in-hospital deaths. Increased expression of NLR was an indicator of poor prognosis in COVID-19 patients with CLD. Thus, COVID-19 patients diagnosed with CLD and who show a higher NLR need additional care. METHODS: A retrospective cohort study was performed at the Wuhan Jin Yin-tan Hospital from February 2, 2020 to April 2, 2020. COVID-19 patients diagnosed with CLD or not diagnosed with CLD were enrolled in this study. The clinical characteristics and outcomes of these patients were compared. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/32855361/Clinical_characteristics_of_chronic_liver_disease_with_coronavirus_disease_2019__COVID_19_:_a_cohort_study_in_Wuhan_China_ DB - PRIME DP - Unbound Medicine ER -