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Disease progression patterns and risk factors associated with mortality in deceased patients with COVID-19 in Hubei Province, China.
Immun Inflamm Dis. 2020 12; 8(4):584-594.II

Abstract

BACKGROUND

Detailed descriptions of the patterns of disease progression of deceased coronavirus disease 2019 (COVID-19) patients have not been well explored.

OBJECTIVES

This study sought to explore disease progression patterns and risk factors associated with mortality of deceased patients with COVID-19.

MATERIALS AND METHODS

Epidemiological, clinical, laboratory, and imaging data (from 15 January to 26 March 2020) of laboratory-confirmed COVID-19 patients were collected retrospectively from two hospitals, Hubei province, China. Disease progression patterns of patients were analyzed based on laboratory data, radiological findings, and Sequential Organ Failure Assessment (SOFA) score. Risk factors associated with death were analyzed.

RESULTS

A total of 792 patients were enrolled in this study, of whom 68 died and 724 survived. Complications during hospitalization, such as sepsis, severe acute respiratory distress syndrome, acute cardiac injury, and acute kidney injury, were markedly more frequent in deceased patients than in surviving patients. Deceased patients presented progressive deterioration pattern in laboratory variables, chest computed tomography evaluation, and SOFA score, while surviving patients presented initial deterioration to peak level involvement followed by improvement pattern over time. Days 10 to 14 after illness onset was a critical stage of disease course. Older age, number of preexisting comorbidities ≥2, and SOFA score were independently associated with death for COVID-19.

CONCLUSIONS

Multiorgan dysfunction was common in deceased COVID-19 patients. Deceased patients presented progressive deterioration pattern, while surviving patients presented a relatively stable pattern during disease progression. Older age, number of preexisting comorbidities ≥2, and SOFA score were independent risk factors for death for COVID-19.

Authors+Show Affiliations

Department of Radiology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.Department of Radiology, Yichang Central People's Hospital, The First College of Clinical Medical Science, Yichang, China.Department of Respiratory Medicine, The First People's Hospital of Ziyang, West China Hospital Sichuan University-Ziyang Hospital, Ziyang, China.Department of Radiology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.Department of Radiology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.Department of Radiology, Hubei Province Academy of Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.Department of Internal Medicine, Campus Virchow Clinic, German Heart Center Berlin, Charité University Medicine, Berlin, Germany.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32857453

Citation

Chen, Liang, et al. "Disease Progression Patterns and Risk Factors Associated With Mortality in Deceased Patients With COVID-19 in Hubei Province, China." Immunity, Inflammation and Disease, vol. 8, no. 4, 2020, pp. 584-594.
Chen L, Liu S, Tian J, et al. Disease progression patterns and risk factors associated with mortality in deceased patients with COVID-19 in Hubei Province, China. Immun Inflamm Dis. 2020;8(4):584-594.
Chen, L., Liu, S., Tian, J., Pan, H., Liu, Y., Hu, J., Wang, M., & Hou, X. (2020). Disease progression patterns and risk factors associated with mortality in deceased patients with COVID-19 in Hubei Province, China. Immunity, Inflammation and Disease, 8(4), 584-594. https://doi.org/10.1002/iid3.343
Chen L, et al. Disease Progression Patterns and Risk Factors Associated With Mortality in Deceased Patients With COVID-19 in Hubei Province, China. Immun Inflamm Dis. 2020;8(4):584-594. PubMed PMID: 32857453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disease progression patterns and risk factors associated with mortality in deceased patients with COVID-19 in Hubei Province, China. AU - Chen,Liang, AU - Liu,Song, AU - Tian,Juncai, AU - Pan,Haisong, AU - Liu,Yu, AU - Hu,Jun, AU - Wang,Maoren, AU - Hou,Xuewen, Y1 - 2020/08/28/ PY - 2020/07/28/received PY - 2020/08/14/accepted PY - 2020/8/29/pubmed PY - 2020/11/25/medline PY - 2020/8/29/entrez KW - COVID-19 KW - SARS-CoV-2 KW - SOFA score KW - disease progression pattern SP - 584 EP - 594 JF - Immunity, inflammation and disease JO - Immun Inflamm Dis VL - 8 IS - 4 N2 - BACKGROUND: Detailed descriptions of the patterns of disease progression of deceased coronavirus disease 2019 (COVID-19) patients have not been well explored. OBJECTIVES: This study sought to explore disease progression patterns and risk factors associated with mortality of deceased patients with COVID-19. MATERIALS AND METHODS: Epidemiological, clinical, laboratory, and imaging data (from 15 January to 26 March 2020) of laboratory-confirmed COVID-19 patients were collected retrospectively from two hospitals, Hubei province, China. Disease progression patterns of patients were analyzed based on laboratory data, radiological findings, and Sequential Organ Failure Assessment (SOFA) score. Risk factors associated with death were analyzed. RESULTS: A total of 792 patients were enrolled in this study, of whom 68 died and 724 survived. Complications during hospitalization, such as sepsis, severe acute respiratory distress syndrome, acute cardiac injury, and acute kidney injury, were markedly more frequent in deceased patients than in surviving patients. Deceased patients presented progressive deterioration pattern in laboratory variables, chest computed tomography evaluation, and SOFA score, while surviving patients presented initial deterioration to peak level involvement followed by improvement pattern over time. Days 10 to 14 after illness onset was a critical stage of disease course. Older age, number of preexisting comorbidities ≥2, and SOFA score were independently associated with death for COVID-19. CONCLUSIONS: Multiorgan dysfunction was common in deceased COVID-19 patients. Deceased patients presented progressive deterioration pattern, while surviving patients presented a relatively stable pattern during disease progression. Older age, number of preexisting comorbidities ≥2, and SOFA score were independent risk factors for death for COVID-19. SN - 2050-4527 UR - https://www.unboundmedicine.com/medline/citation/32857453/Disease_progression_patterns_and_risk_factors_associated_with_mortality_in_deceased_patients_with_COVID_19_in_Hubei_Province_China_ L2 - https://doi.org/10.1002/iid3.343 DB - PRIME DP - Unbound Medicine ER -