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Retrospective analysis of clinical characteristics of 405 patients with COVID-19.
J Int Med Res. 2020 Aug; 48(8):300060520949039.JI

Abstract

OBJECTIVE

This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS

We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.

RESULTS

The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.

CONCLUSION

SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.

Authors+Show Affiliations

Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. Jianghan University, Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32865077

Citation

Zhan, Ting, et al. "Retrospective Analysis of Clinical Characteristics of 405 Patients With COVID-19." The Journal of International Medical Research, vol. 48, no. 8, 2020, p. 300060520949039.
Zhan T, Liu M, Tang Y, et al. Retrospective analysis of clinical characteristics of 405 patients with COVID-19. J Int Med Res. 2020;48(8):300060520949039.
Zhan, T., Liu, M., Tang, Y., Han, Z., Cheng, X., Deng, J., Chen, X., Tian, X., & Huang, X. (2020). Retrospective analysis of clinical characteristics of 405 patients with COVID-19. The Journal of International Medical Research, 48(8), 300060520949039. https://doi.org/10.1177/0300060520949039
Zhan T, et al. Retrospective Analysis of Clinical Characteristics of 405 Patients With COVID-19. J Int Med Res. 2020;48(8):300060520949039. PubMed PMID: 32865077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective analysis of clinical characteristics of 405 patients with COVID-19. AU - Zhan,Ting, AU - Liu,Meng, AU - Tang,Yalin, AU - Han,Zheng, AU - Cheng,Xueting, AU - Deng,Junsheng, AU - Chen,Xiaoli, AU - Tian,Xia, AU - Huang,Xiaodong, PY - 2020/9/1/entrez PY - 2020/9/1/pubmed PY - 2020/9/8/medline KW - COVID-19 KW - SARS-CoV-2 KW - Wuhan KW - clinical characteristics KW - fever KW - gastrointestinal symptoms SP - 300060520949039 EP - 300060520949039 JF - The Journal of international medical research JO - J Int Med Res VL - 48 IS - 8 N2 - OBJECTIVE: This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. RESULTS: The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. CONCLUSION: SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/32865077/Retrospective_analysis_of_clinical_characteristics_of_405_patients_with_COVID_19_ L2 - https://journals.sagepub.com/doi/10.1177/0300060520949039?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -