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Recent advances in immunologic reactivity in otitis media with effusion.
J Allergy Clin Immunol. 1988 May; 81(5 Pt 2):1004-9.JA

Abstract

The role of IgE-mediated hypersensitivity in the development of middle ear disease has not been completely resolved. However, on the basis of our investigations and those of other laboratories, we suggest that approximately two thirds of patients with chronic recurrent otitis media do not have allergies. The other third may have allergic rhinitis, and this allergic rhinitis could play a direct role in producing eustachian tube dysfunction in recurrent otitis media. However, viral infections of the upper respiratory tract may also induce IgE-mediated release of mast cell inflammatory mediators, and could cause otitis media on the basis of viral infection alone. Subtle immunologic deficiencies involving the IgG2 subclass and other immunoglobulin subclasses may also be lower in otitis-prone children, and this may be a genetically inherited disorder. Finally, the possibility of food allergy in otitis media must be considered, particularly in the young otitis-prone child with chronic recurrent otitis media.

Authors+Show Affiliations

Department of Speech-Language Pathology and Audiology, State College of New York, Buffalo.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3286724

Citation

Bernstein, J M.. "Recent Advances in Immunologic Reactivity in Otitis Media With Effusion." The Journal of Allergy and Clinical Immunology, vol. 81, no. 5 Pt 2, 1988, pp. 1004-9.
Bernstein JM. Recent advances in immunologic reactivity in otitis media with effusion. J Allergy Clin Immunol. 1988;81(5 Pt 2):1004-9.
Bernstein, J. M. (1988). Recent advances in immunologic reactivity in otitis media with effusion. The Journal of Allergy and Clinical Immunology, 81(5 Pt 2), 1004-9.
Bernstein JM. Recent Advances in Immunologic Reactivity in Otitis Media With Effusion. J Allergy Clin Immunol. 1988;81(5 Pt 2):1004-9. PubMed PMID: 3286724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in immunologic reactivity in otitis media with effusion. A1 - Bernstein,J M, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 1004 EP - 9 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 81 IS - 5 Pt 2 N2 - The role of IgE-mediated hypersensitivity in the development of middle ear disease has not been completely resolved. However, on the basis of our investigations and those of other laboratories, we suggest that approximately two thirds of patients with chronic recurrent otitis media do not have allergies. The other third may have allergic rhinitis, and this allergic rhinitis could play a direct role in producing eustachian tube dysfunction in recurrent otitis media. However, viral infections of the upper respiratory tract may also induce IgE-mediated release of mast cell inflammatory mediators, and could cause otitis media on the basis of viral infection alone. Subtle immunologic deficiencies involving the IgG2 subclass and other immunoglobulin subclasses may also be lower in otitis-prone children, and this may be a genetically inherited disorder. Finally, the possibility of food allergy in otitis media must be considered, particularly in the young otitis-prone child with chronic recurrent otitis media. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/3286724/Recent_advances_in_immunologic_reactivity_in_otitis_media_with_effusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(88)90169-8 DB - PRIME DP - Unbound Medicine ER -