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Repositioning of Drugs to Counter COVID-19 Pandemic - An Insight.
Curr Pharm Biotechnol. 2021; 22(2):192-199.CP

Abstract

COVID-19 is a pandemic, caused by the novel coronavirus 2 (SARS-CoV-2) which is a severe acute respiratory syndrome. The devastating impact of this novel coronavirus outbreak has necessitated the need for rapid and effective antiviral therapies against SARS-CoV-2 to control the spread of the disease and importantly, alleviate the severe life-threatening symptoms and disorders. Drug repurposing strategy offers an attractive, immediate and realistic approach to tackle this growing pandemic of COVID-19. Due to the similarities with the SARS-CoV-1 virus and phylogenetic relation to the MERS-CoV virus, accelerated screening of approved drugs and the development of repositioning strategies have proved to be critical for the survival of many COVID-19 patients. Numerous scientific investigations from the initial years of the coronavirus outbreak along with upcoming advances of immunotherapy and vaccines, may prove to be beneficial. Currently, several repurposing strategies are under different phases of clinical trials and provide a definitive framework for the development of future therapies for the effective treatment of COVID-19. This review article summarizes the latest developments and trends in drug repurposing strategy for COVID-19 treatment.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Akilesh SM
Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty - 643001, The Nilgiris, Tamil Nadu, India.
J R
Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty - 643001, The Nilgiris, Tamil Nadu, India.
Palanisamy D
Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education & Research - 643001, The Nilgiris, Tamil Nadu, India.
Wadhwani A
Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty - 643001, The Nilgiris, Tamil Nadu, India.

MeSH

Antiviral AgentsCOVID-19Clinical Trials as TopicDrug RepositioningHumansPandemicsSARS-CoV-2COVID-19 Drug Treatment

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32867651

Citation

Akilesh, Sai M., et al. "Repositioning of Drugs to Counter COVID-19 Pandemic - an Insight." Current Pharmaceutical Biotechnology, vol. 22, no. 2, 2021, pp. 192-199.
Akilesh SM, J R, Palanisamy D, et al. Repositioning of Drugs to Counter COVID-19 Pandemic - An Insight. Curr Pharm Biotechnol. 2021;22(2):192-199.
Akilesh, S. M., J, R., Palanisamy, D., & Wadhwani, A. (2021). Repositioning of Drugs to Counter COVID-19 Pandemic - An Insight. Current Pharmaceutical Biotechnology, 22(2), 192-199. https://doi.org/10.2174/1389201021999200820155927
Akilesh SM, et al. Repositioning of Drugs to Counter COVID-19 Pandemic - an Insight. Curr Pharm Biotechnol. 2021;22(2):192-199. PubMed PMID: 32867651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repositioning of Drugs to Counter COVID-19 Pandemic - An Insight. AU - Akilesh,Sai M, AU - J,Rajesh, AU - Palanisamy,Dhanabal, AU - Wadhwani,Ashish, PY - 2020/04/29/received PY - 2020/06/19/revised PY - 2020/07/23/accepted PY - 2020/9/2/pubmed PY - 2021/4/13/medline PY - 2020/9/2/entrez KW - COVID-19 KW - Coronavirus KW - SARS-CoV-2 KW - drug repurposing KW - infectious diseases KW - viruses SP - 192 EP - 199 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 22 IS - 2 N2 - COVID-19 is a pandemic, caused by the novel coronavirus 2 (SARS-CoV-2) which is a severe acute respiratory syndrome. The devastating impact of this novel coronavirus outbreak has necessitated the need for rapid and effective antiviral therapies against SARS-CoV-2 to control the spread of the disease and importantly, alleviate the severe life-threatening symptoms and disorders. Drug repurposing strategy offers an attractive, immediate and realistic approach to tackle this growing pandemic of COVID-19. Due to the similarities with the SARS-CoV-1 virus and phylogenetic relation to the MERS-CoV virus, accelerated screening of approved drugs and the development of repositioning strategies have proved to be critical for the survival of many COVID-19 patients. Numerous scientific investigations from the initial years of the coronavirus outbreak along with upcoming advances of immunotherapy and vaccines, may prove to be beneficial. Currently, several repurposing strategies are under different phases of clinical trials and provide a definitive framework for the development of future therapies for the effective treatment of COVID-19. This review article summarizes the latest developments and trends in drug repurposing strategy for COVID-19 treatment. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/32867651/Repositioning_of_Drugs_to_Counter_COVID_19_Pandemic___An_Insight_ DB - PRIME DP - Unbound Medicine ER -