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The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.
Transl Neurodegener. 2020 09 01; 9(1):34.TN

Abstract

In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D3 supplementation in PD patients. In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission, interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future.

Authors+Show Affiliations

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China. Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha, 410078, China. Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, 410078, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. wangchunyu@csu.edu.cn. Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. wangchunyu@csu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32867847

Citation

Lv, Lingling, et al. "The Relationships of Vitamin D, Vitamin D Receptor Gene Polymorphisms, and Vitamin D Supplementation With Parkinson's Disease." Translational Neurodegeneration, vol. 9, no. 1, 2020, p. 34.
Lv L, Tan X, Peng X, et al. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease. Transl Neurodegener. 2020;9(1):34.
Lv, L., Tan, X., Peng, X., Bai, R., Xiao, Q., Zou, T., Tan, J., Zhang, H., & Wang, C. (2020). The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease. Translational Neurodegeneration, 9(1), 34. https://doi.org/10.1186/s40035-020-00213-2
Lv L, et al. The Relationships of Vitamin D, Vitamin D Receptor Gene Polymorphisms, and Vitamin D Supplementation With Parkinson's Disease. Transl Neurodegener. 2020 09 1;9(1):34. PubMed PMID: 32867847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease. AU - Lv,Lingling, AU - Tan,Xuling, AU - Peng,Xinke, AU - Bai,Rongrong, AU - Xiao,Qile, AU - Zou,Ting, AU - Tan,Jieqiong, AU - Zhang,Hainan, AU - Wang,Chunyu, Y1 - 2020/09/01/ PY - 2020/06/14/received PY - 2020/08/06/accepted PY - 2020/9/2/entrez PY - 2020/9/2/pubmed PY - 2021/10/1/medline KW - Dopaminergic neurotransmission KW - Neuroprotective KW - Parkinson’s disease KW - VDR gene polymorphisms KW - Vitamin D KW - Vitamin D3 supplementation SP - 34 EP - 34 JF - Translational neurodegeneration JO - Transl Neurodegener VL - 9 IS - 1 N2 - In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D3 supplementation in PD patients. In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission, interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future. SN - 2047-9158 UR - https://www.unboundmedicine.com/medline/citation/32867847/The_relationships_of_vitamin_D_vitamin_D_receptor_gene_polymorphisms_and_vitamin_D_supplementation_with_Parkinson's_disease_ L2 - https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00213-2 DB - PRIME DP - Unbound Medicine ER -