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Unethical not to Investigate Radiotherapy for COVID-19.
Dose Response. 2020 Jul-Sep; 18(3):1559325820950104.DR

Abstract

The primum non nocere letter by Boon et al. urged caution and careful examination of the evidence and logistics of low-dose radiotherapy in COVID-19 patients. This is exactly what was requested in March and what has occurred since late April 2020 when the first phase I/II clinical trial was approved at the Winship Cancer Institute, Emory University Hospital. The preprint of day-7 interim results by the investigators concluded, "In a small pilot trial of 5 oxygen-dependent patients with COVID-19 pneumonia, low-dose whole-lung radiation led to rapid improvement in clinical status, encephalopathy, and radiographic infiltrates without acute toxicity or worsening the cytokine storm. Low-dose whole-lung radiation appears to be safe, shows early promise of efficacy, and warrants larger prospective trials." Preliminary results from another clinical trial gave similar results. In conclusion, the authors believe it would be unethical not to investigate radiotherapy as a potential remedy against COVID-19 induced pneumonia.

Authors+Show Affiliations

Cuttler & Associates, Vaughan, Ontario, Canada.Bevelacqua Resources, Richland, Washington, DC, USA.Medical Physics and Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32868978

Citation

Cuttler, Jerry M., et al. "Unethical Not to Investigate Radiotherapy for COVID-19." Dose-response : a Publication of International Hormesis Society, vol. 18, no. 3, 2020, p. 1559325820950104.
Cuttler JM, Bevelacqua JJ, Mortazavi SMJ. Unethical not to Investigate Radiotherapy for COVID-19. Dose Response. 2020;18(3):1559325820950104.
Cuttler, J. M., Bevelacqua, J. J., & Mortazavi, S. M. J. (2020). Unethical not to Investigate Radiotherapy for COVID-19. Dose-response : a Publication of International Hormesis Society, 18(3), 1559325820950104. https://doi.org/10.1177/1559325820950104
Cuttler JM, Bevelacqua JJ, Mortazavi SMJ. Unethical Not to Investigate Radiotherapy for COVID-19. Dose Response. 2020 Jul-Sep;18(3):1559325820950104. PubMed PMID: 32868978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unethical not to Investigate Radiotherapy for COVID-19. AU - Cuttler,Jerry M, AU - Bevelacqua,Joseph J, AU - Mortazavi,S M J, Y1 - 2020/08/18/ PY - 2020/9/2/entrez PY - 2020/9/2/pubmed PY - 2020/9/2/medline KW - COVID-19 KW - low dose radiation KW - lung radiotherapy KW - pneumonia SP - 1559325820950104 EP - 1559325820950104 JF - Dose-response : a publication of International Hormesis Society JO - Dose Response VL - 18 IS - 3 N2 - The primum non nocere letter by Boon et al. urged caution and careful examination of the evidence and logistics of low-dose radiotherapy in COVID-19 patients. This is exactly what was requested in March and what has occurred since late April 2020 when the first phase I/II clinical trial was approved at the Winship Cancer Institute, Emory University Hospital. The preprint of day-7 interim results by the investigators concluded, "In a small pilot trial of 5 oxygen-dependent patients with COVID-19 pneumonia, low-dose whole-lung radiation led to rapid improvement in clinical status, encephalopathy, and radiographic infiltrates without acute toxicity or worsening the cytokine storm. Low-dose whole-lung radiation appears to be safe, shows early promise of efficacy, and warrants larger prospective trials." Preliminary results from another clinical trial gave similar results. In conclusion, the authors believe it would be unethical not to investigate radiotherapy as a potential remedy against COVID-19 induced pneumonia. SN - 1559-3258 UR - https://www.unboundmedicine.com/medline/citation/32868978/Unethical_not_to_Investigate_Radiotherapy_for_COVID_19_ L2 - https://journals.sagepub.com/doi/10.1177/1559325820950104?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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