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Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms.
Mol Neurobiol. 2020 Dec; 57(12):5263-5275.MN

Abstract

Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement.

Authors+Show Affiliations

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammadhadiarabi@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32869183

Citation

Mohammadi, Soheil, et al. "Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms." Molecular Neurobiology, vol. 57, no. 12, 2020, pp. 5263-5275.
Mohammadi S, Moosaie F, Aarabi MH. Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Mol Neurobiol. 2020;57(12):5263-5275.
Mohammadi, S., Moosaie, F., & Aarabi, M. H. (2020). Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Molecular Neurobiology, 57(12), 5263-5275. https://doi.org/10.1007/s12035-020-02094-y
Mohammadi S, Moosaie F, Aarabi MH. Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Mol Neurobiol. 2020;57(12):5263-5275. PubMed PMID: 32869183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. AU - Mohammadi,Soheil, AU - Moosaie,Fatemeh, AU - Aarabi,Mohammad Hadi, Y1 - 2020/09/01/ PY - 2020/07/07/received PY - 2020/08/25/accepted PY - 2020/9/2/pubmed PY - 2020/10/21/medline PY - 2020/9/2/entrez KW - Central nervous system KW - Coronavirus disease 2019 KW - Cytokines KW - Immunologic pathways KW - Neurological complications KW - SARS-CoV-2 SP - 5263 EP - 5275 JF - Molecular neurobiology JO - Mol Neurobiol VL - 57 IS - 12 N2 - Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/32869183/Understanding_the_Immunologic_Characteristics_of_Neurologic_Manifestations_of_SARS_CoV_2_and_Potential_Immunological_Mechanisms_ L2 - https://dx.doi.org/10.1007/s12035-020-02094-y DB - PRIME DP - Unbound Medicine ER -