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Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients.
J Neurosci Res. 2020 12; 98(12):2376-2383.JN

Abstract

Manifestation of neurological symptoms in certain patients of coronavirus disease-2019 (COVID-19) has warranted for their virus-induced etiogenesis. SARS-CoV-2, the causative agent of COVID-19, belongs to the genus of betacoronaviruses which also includes SARS-CoV-1 and MERS-CoV; causative agents for severe acute respiratory syndrome (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012, respectively. Studies demonstrating the neural invasion of SARS-CoV-2 in vivo are still scarce, although such characteristics of certain other betacoronaviruses are well demonstrated in the literature. Based on the recent evidence for the presence of SARS-CoV-2 host cell entry receptors in specific components of the human nervous and vascular tissue, a neural (olfactory and/or vagal), and a hematogenous-crossing the blood-brain barrier, routes have been proposed. The neurological symptoms in COVID-19 may also arise as a consequence of the "cytokine storm" (characteristically present in severe disease) induced neuroinflammation, or co-morbidities. There is also a possibility that, there may be multiple routes of SARS-CoV-2 entry into the brain, or multiple mechanisms can be involved in the pathogenesis of the neurological symptoms. In this review article, we have discussed the possible routes of SARS-CoV-2 brain entry based on the emerging evidence for this virus, and that available for other betacoronaviruses in literature.

Authors+Show Affiliations

Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. National Brain Research Center, Manesar, India.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. Pittsburgh Center for Pain Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. New York University (NYU) Langone Health Center, NYU Robert I Grossman School of Medicine, New York, NY, USA.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. Department of Anatomy, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India. Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32869376

Citation

Kumar, Ashutosh, et al. "Possible Routes of SARS-CoV-2 Invasion in Brain: in Context of Neurological Symptoms in COVID-19 Patients." Journal of Neuroscience Research, vol. 98, no. 12, 2020, pp. 2376-2383.
Kumar A, Pareek V, Prasoon P, et al. Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients. J Neurosci Res. 2020;98(12):2376-2383.
Kumar, A., Pareek, V., Prasoon, P., Faiq, M. A., Kumar, P., Kumari, C., & Narayan, R. K. (2020). Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients. Journal of Neuroscience Research, 98(12), 2376-2383. https://doi.org/10.1002/jnr.24717
Kumar A, et al. Possible Routes of SARS-CoV-2 Invasion in Brain: in Context of Neurological Symptoms in COVID-19 Patients. J Neurosci Res. 2020;98(12):2376-2383. PubMed PMID: 32869376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients. AU - Kumar,Ashutosh, AU - Pareek,Vikas, AU - Prasoon,Pranav, AU - Faiq,Muneeb A, AU - Kumar,Pavan, AU - Kumari,Chiman, AU - Narayan,Ravi K, Y1 - 2020/08/31/ PY - 2020/06/02/received PY - 2020/07/21/revised PY - 2020/08/09/accepted PY - 2020/9/2/pubmed PY - 2020/10/29/medline PY - 2020/9/2/entrez KW - COVID-19 KW - SARS-CoV-2 KW - blood-brain barrier KW - neural invasion KW - neurological symptoms SP - 2376 EP - 2383 JF - Journal of neuroscience research JO - J Neurosci Res VL - 98 IS - 12 N2 - Manifestation of neurological symptoms in certain patients of coronavirus disease-2019 (COVID-19) has warranted for their virus-induced etiogenesis. SARS-CoV-2, the causative agent of COVID-19, belongs to the genus of betacoronaviruses which also includes SARS-CoV-1 and MERS-CoV; causative agents for severe acute respiratory syndrome (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012, respectively. Studies demonstrating the neural invasion of SARS-CoV-2 in vivo are still scarce, although such characteristics of certain other betacoronaviruses are well demonstrated in the literature. Based on the recent evidence for the presence of SARS-CoV-2 host cell entry receptors in specific components of the human nervous and vascular tissue, a neural (olfactory and/or vagal), and a hematogenous-crossing the blood-brain barrier, routes have been proposed. The neurological symptoms in COVID-19 may also arise as a consequence of the "cytokine storm" (characteristically present in severe disease) induced neuroinflammation, or co-morbidities. There is also a possibility that, there may be multiple routes of SARS-CoV-2 entry into the brain, or multiple mechanisms can be involved in the pathogenesis of the neurological symptoms. In this review article, we have discussed the possible routes of SARS-CoV-2 brain entry based on the emerging evidence for this virus, and that available for other betacoronaviruses in literature. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/32869376/Possible_routes_of_SARS_CoV_2_invasion_in_brain:_In_context_of_neurological_symptoms_in_COVID_19_patients_ L2 - https://doi.org/10.1002/jnr.24717 DB - PRIME DP - Unbound Medicine ER -