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Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding.
Ocul Immunol Inflamm. 2020 Nov 16; 28(8):1269-1279.OI

Abstract

The recently identified novel coronavirus (CoV), the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes the coronavirus disease 2019 (COVID-19). While published data about other highly infectious human COVs [that is, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV)] provide helpful information about the infectivity of SARS-CoV-2, there is limited understanding surrounding knowledge of ocular manifestation of the virus. This paper reviews published data which reveal the presence of SARS-CoV-2 RNA in tears and conjunctival scrappings of some COVID-19 patients by real-time-polymerase chain reaction assay, although the detection rate is low compared to samples from respiratory sites. Nevertheless, the ocular complications from SARS-CoV-2 infection are uncommon. The evidence partly supports the eye as a portal of entry for SARS-CoV-2 to infect respiratory cells or viral shedding from respiratory cells via the nasolacrimal duct unto the ocular surface. The possibility of ocular secretions as source for SARS-CoV-2 to spread externally has substantial public health implications.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

Department of Biomedical Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast , Cape Coast, Ghana.

MeSH

BetacoronavirusCOVID-19ComorbidityConjunctivaCoronavirus InfectionsDisease Transmission, InfectiousEye Infections, ViralHumansPandemicsPneumonia, ViralSARS-CoV-2Virus Shedding

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32870054

Citation

Ocansey, Stephen, et al. "Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding." Ocular Immunology and Inflammation, vol. 28, no. 8, 2020, pp. 1269-1279.

Ocansey S, Abu EK, Abraham CH, et al. Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding. Ocul Immunol Inflamm. 2020;28(8):1269-1279.

Ocansey, S., Abu, E. K., Abraham, C. H., Owusu-Ansah, A., Boadi-Kusi, S. B., Ilechie, A. A., & Acheampong, D. O. (2020). Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding. Ocular Immunology and Inflammation, 28(8), 1269-1279. https://doi.org/10.1080/09273948.2020.1799035

Ocansey S, et al. Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding. Ocul Immunol Inflamm. 2020 Nov 16;28(8):1269-1279. PubMed PMID: 32870054.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Ocular Symptoms of SARS-CoV-2: Indication of Possible Ocular Transmission or Viral Shedding. AU - Ocansey,Stephen, AU - Abu,Emmanuel Kwasi, AU - Abraham,Carl Halladay, AU - Owusu-Ansah,Andrew, AU - Boadi-Kusi,Samuel Bert, AU - Ilechie,Alex Azuka, AU - Acheampong,Desmond Omane, Y1 - 2020/09/01/ PY - 2020/9/2/pubmed PY - 2020/11/27/medline PY - 2020/9/2/entrez KW - COVID-19 KW - Coronavirus KW - infection KW - ocular surface KW - shedding KW - transmission SP - 1269 EP - 1279 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 28 IS - 8 N2 - The recently identified novel coronavirus (CoV), the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes the coronavirus disease 2019 (COVID-19). While published data about other highly infectious human COVs [that is, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV)] provide helpful information about the infectivity of SARS-CoV-2, there is limited understanding surrounding knowledge of ocular manifestation of the virus. This paper reviews published data which reveal the presence of SARS-CoV-2 RNA in tears and conjunctival scrappings of some COVID-19 patients by real-time-polymerase chain reaction assay, although the detection rate is low compared to samples from respiratory sites. Nevertheless, the ocular complications from SARS-CoV-2 infection are uncommon. The evidence partly supports the eye as a portal of entry for SARS-CoV-2 to infect respiratory cells or viral shedding from respiratory cells via the nasolacrimal duct unto the ocular surface. The possibility of ocular secretions as source for SARS-CoV-2 to spread externally has substantial public health implications. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/32870054/Ocular_Symptoms_of_SARS_CoV_2:_Indication_of_Possible_Ocular_Transmission_or_Viral_Shedding_ DB - PRIME DP - Unbound Medicine ER -