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Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection.
Ocul Immunol Inflamm. 2020 Aug 17; 28(6):916-921.OI

Abstract

PURPOSES

To describe the prevalence of ocular features among COVID-19 patients and their relationship with clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients.

METHODS

172 COVID-19 patients were evaluated for presence of ocular manifestations. Clinical and laboratory data were also reviewed. Conjunctival swabs were analyzed for SARS-CoV-2 by RT-PCR.

RESULTS

Forty-five patients (26.2%) reported ocular manifestations. Patients treated with CPAP were more likely to have ocular abnormalities (p <.01). The presence of ocular symptoms was not associated with more significant alterations on blood tests. Conjunctival swabs from patients with suspect conjunctivitis yielded negative results for SARS-CoV-2.

CONCLUSIONS

Ocular features are not infrequent in COVID-19 patients, but the presence of SARS-CoV-2 in ocular secretions is low. Ocular manifestations in hospitalized COVID-19 patients can also be a consequence of respiratory support therapy. Prevention of possible transmission through ocular secretions is still recommended.

Authors+Show Affiliations

Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University , Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32870738

Citation

Cavalleri, Michele, et al. "Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection." Ocular Immunology and Inflammation, vol. 28, no. 6, 2020, pp. 916-921.
Cavalleri M, Brambati M, Starace V, et al. Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection. Ocul Immunol Inflamm. 2020;28(6):916-921.
Cavalleri, M., Brambati, M., Starace, V., Capone, L., Nadin, F., Pederzolli, M., Gorgoni, F., Di Biase, C., Corbelli, E., Battista, M., Grazioli Moretti, A., Grosso, D., & Bandello, F. (2020). Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection. Ocular Immunology and Inflammation, 28(6), 916-921. https://doi.org/10.1080/09273948.2020.1781198
Cavalleri M, et al. Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection. Ocul Immunol Inflamm. 2020 Aug 17;28(6):916-921. PubMed PMID: 32870738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection. AU - Cavalleri,Michele, AU - Brambati,Maria, AU - Starace,Vincenzo, AU - Capone,Luigi, AU - Nadin,Francesco, AU - Pederzolli,Matteo, AU - Gorgoni,Francesca, AU - Di Biase,Carlo, AU - Corbelli,Eleonora, AU - Battista,Marco, AU - Grazioli Moretti,Alessio, AU - Grosso,Domenico, AU - Bandello,Francesco, PY - 2020/9/2/entrez PY - 2020/9/2/pubmed PY - 2020/9/2/medline KW - COVID-19 KW - RT-PCR KW - SARS-CoV-2 KW - conjunctivitis SP - 916 EP - 921 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. VL - 28 IS - 6 N2 - PURPOSES: To describe the prevalence of ocular features among COVID-19 patients and their relationship with clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients. METHODS: 172 COVID-19 patients were evaluated for presence of ocular manifestations. Clinical and laboratory data were also reviewed. Conjunctival swabs were analyzed for SARS-CoV-2 by RT-PCR. RESULTS: Forty-five patients (26.2%) reported ocular manifestations. Patients treated with CPAP were more likely to have ocular abnormalities (p <.01). The presence of ocular symptoms was not associated with more significant alterations on blood tests. Conjunctival swabs from patients with suspect conjunctivitis yielded negative results for SARS-CoV-2. CONCLUSIONS: Ocular features are not infrequent in COVID-19 patients, but the presence of SARS-CoV-2 in ocular secretions is low. Ocular manifestations in hospitalized COVID-19 patients can also be a consequence of respiratory support therapy. Prevention of possible transmission through ocular secretions is still recommended. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/32870738/Ocular_Features_and_Associated_Systemic_Findings_in_SARS_CoV_2_Infection_ L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2020.1781198 DB - PRIME DP - Unbound Medicine ER -